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001-es BibID:	BIBFORM006864
Első szerző:	Mohás Márton
Cím:	Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome / Mohas, M., Szigeti, N., Marko, L., Molnar, G. A., Cseh, J., Laczy, B., Tamasko, M., Balla, J., Kappelmayer, J., Wagner, L., Wagner, Z., Csiky, B., Nagy, J., Wittmann, I.
Dátum:	2008
Megjegyzések:	Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome. METHODS: In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively). RESULTS: Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p < 0.001) and correlated with serum total protein (r = -0.549, p < 0.001), serum albumin (r = -0.596, p < 0.001), proteinuria (r = 0.456, p < 0.001) and serum total cholesterol (r = 0.523, p < 0.001). LDH isozyme pattern was analysed in three subgroups of the patients. Serum LDH-2 activity was higher in the NEPHR subgroup compared with the NON-NEPHR and CONTR subgroups (p < 0.001). Serum LDH-2 activity correlated with serum total protein (r = -0.665, p < 0.001), serum albumin (r = -0.615, p < 0.001), proteinuria (r = 0.694, p < 0.001), and serum total cholesterol (r = 0.723, p < 0.001). Linear regression analysis revealed that serum total protein proved to be an independent predictor of serum total LDH activity, while serum total protein and proteinuria were predictors of LDH-2. CONCLUSIONS: These findings suggest that serum total LDH activity might be a marker of the activity of the nephrotic syndrome.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Aged Biological Markers/blood Cohort Studies Cross-Sectional Studies Enzyme Activation/physiology Female Humans Male Middle Aged Retrospective Studies
Megjelenés:	Kidney and Blood Pressure Research. - 31 : 1 (2008), p. 47-54. -
További szerzők:	Szigeti Nóra Markó Lajos Molnár Gergő Attila Cseh Judit Laczy Boglárka Tamaskó Mónika Balla József (1959-) (belgyógyász, nephrológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Wagner László Wagner Zoltán Csiky Botond Nagy Judit (kutató) Wittmann István
Internet cím:	elektronikus változat elektronikus változat DOI
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