Találati lista | Tudóstér

001-es BibID:	BIBFORM007021
Első szerző:	Márkász László (gyermekgyógyász)
Cím:	Effect of frequently used chemotherapeutic drugs on cytotoxic activity of human cytotoxic T-lymphocytes / Laszlo Markasz, Henriette Skribek, Michael Uhlin, Rita Otvos, Emilie Flaberg, Staffan Eksborg, Eva Olah, Gyorgy Stuber, Laszlo Szekely
Dátum:	2008
Megjegyzések:	Tumors are considered to be possible targets of immunotherapy using stimulated and expanded cytotoxic T-lymphocytes (CTL). It is important to consider the drug-induced effects when chemotherapeutic regimens and CTL-mediated immunotherapy is planned to be used in parallel. In this study, we characterized the effect of 29 frequently used chemotherapeutic agents on the cytotoxic activity of autologous and allogeneic CTLs. We found that treatment of CTLs with the following drugs: docetaxel, vincristine, chlorambucil, mitomycin C, oxaliplatin, doxorubicin, and bleomycin effectively inhibited CTL-mediated killing, without affecting their viability. On the other hand, the following drugs enhanced or permitted efficient CTL-mediated killing in vitro at concentrations comparable with the maximally achieved therapeutic concentration in vivo in humans: daunorubicin, prednisolone, vinorelbine, cisplatin, methotrexate, hydroxyurea, cytarabine, cyclophosphamide, topotecan, epirubicin, fluorouracil, carboplatin, asparaginase, 6-mercaptopurine, and bortezomib. Our results could potentially be used in the future to design new CTL-based adjuvant immunotherapy protocols.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Immunotherapy. - 31 : 3 (2008), p. 283-293. -
További szerzők:	Skribek, Henriette Uhlin, Michael Ötvös Rita (1979-) (vegyész) Flaberg, Emilie Eksborg, Staffan Oláh Éva (1943-2019) (gyermekgyógyász, klinikai genetikus) Stuber György Székely László
Internet cím:	elektronikus változat DOI
Borító:
Saját polcon: