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001-es BibID:	BIBFORM007073
Első szerző:	Koch, Alisa E.
Cím:	Effects of thrombospondin-1 on disease course and angiogenesis in rat adjuvant-induced arthritis / Koch, A. E., Szekanecz, Z., Friedman, J., Haines, G. K., Langman, C. B., Bouck, N. P.
Dátum:	1998
ISSN:	0090-1229 (Print)
Megjegyzések:	Leukocyte extravasation into the synovium is important in rheumatoid arthritis (RA). Thrombospondin (TSP)-1 mediates cell adhesion and migration and inhibits angiogenesis, and it has been implicated in RA. However, little information is available on the role of TSP-1 in arthritis-associated inflammation and neovascularization. Therefore, we analyzed the effects of TSP-1 in adjuvant-induced arthritis (AIA), a rat model for RA. Hydron pellets containing TSP-1 were implanted in one ankle of AIA rats post-adjuvant injection, while the contralateral ankle received sham implants. Body weight loss and joint swelling were determined in comparison to nonimplanted AIA controls. In addition, synovial vessel counts were obtained in TSP-1-versus sham-implanted ankles of the same rat. The implantation of TSP-1 pellets into one ankle resulted in an enhancement of swelling in both ankles. Furthermore, TSP-1 exhibited a biphasic modulatory effect on synovial vessel counts (P < 0.05). In conclusion, TSP-1 implanted into one ankle of AIA rats may augment the severity of the disease. One possible explanation, among others, for the modulating effect of TSP-1 on inflammation may be its effect on arthritis-related angiogenesis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Arthritis, Experimental Arthritis, Rheumatoid Body Weight Disease Models, Animal Dose-Response Relationship, Drug Joints Neovascularization, Pathologic Rats Rats, Inbred Lew Tarsus, Animal Thrombospondin 1
Megjelenés:	Clinical Immunology and Immunopathology. - 86 : 2 (1998), p. 199-208. -
További szerzők:	Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Friedman, J. Haines, G. Kenneth Langman, C. B. Bouck, N. P.
Internet cím:	DOI elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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