Találati lista | Tudóstér

001-es BibID:	BIBFORM007179
Első szerző:	Boda Zoltán (belgyógyász, haematologus, klinikai onkológus)
Cím:	Stem cell therapy : a promising and prospective approach in the treatment of patients with severe Buerger's disease / Zoltan Boda, Miklos Udvardy, Katalin Rázsó, Katalin Farkas, Judit Tóth, Laszlo Jámbor, Zsolt Oláh, Peter Ilonczai, Mariann Szarvas, Janos Kappelmayer, Zoltan Veréb, Eva Rajnavölgyi
Dátum:	2009
Megjegyzések:	No effective blood-flow enhancement therapies are available for patients with severe peripheral arterial disease (SPAD), thus amputation remains the only option for relief of rest pain or gangrene. Autologous bone marrow-derived stem cell therapy (ABMSCT) is an emerging modality to induce angiogenesis from endothelial progenitors. A total of 5 patients with SPAD were treated by ABMSCT using isolated CD34+ cells with characterized phenotype administered by intramuscular injections. The follow-up before and 1, 3, 6, 9, and 12 months after ABMSCT was based on clinical (rest pain, walking distance without pain, non-healing ulcers, ankle-brachial index [ABI]) and laboratory (angiography, duplex and laser ultrasonography, TcPO2) parameters. Significant improvement of pain and walking distance was observed in all patients. Nonhealing ulcers disappeared in 3 patients and became smaller and thinner in 1 patient. The average of ABI improved significantly on the treated limb but did not change on the contralateral limb. New collaterals were detected by angiography in 3 patients, but duplex ultrasonography detected improvement in one patient only. Laser ultrasonography showed a mild significant change, TcPO2 values improved mainly on the foot. Severe adverse events were not observed. We conclude that ABMSCT with isolated CD34+ cells is safe, effective, and results in sustained clinical benefit for patients with SPAD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban stem cell therapy
Megjelenés:	Clinical and Applied Thrombosis/Hemostasis. - 15 : 5 (2009), p. 552-560. -
További szerzők:	Udvardy Miklós (1947-) (belgyógyász, haematológus) Molnárné Rázsó Katalin (1966-) (belgyógyász, haematológus, klinikai onkológus) Farkas Katalin Tóth Judit Jámbor László (1960-) (radiológus) Oláh Zsolt (1974-) (belgyógyász) Ilonczai Péter (1977-) (orvos, belgyógyász, haematológus szakorvos) Szarvas Mariann (1977-) Kappelmayer János (1960-) (laboratóriumi szakorvos) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Rajnavölgyi Éva (1950-) (immunológus)
Internet cím:	elektronikus változat DOI elektronikus változat
Borító:
Saját polcon: