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001-es BibID:	BIBFORM010351
035-os BibID:	(WOS)000266994100004 (scopus)65649131520
Első szerző:	Goda Katalin (biofizikus)
Cím:	Multidrug resistance through the spectacle of P-glycoprotein / Katalin Goda, Zsolt Bacsó, Gábor Szabó
Dátum:	2009
ISSN:	1568-0096 (Print)
Megjegyzések:	P-glycoprotein (Pgp), coded for by the mdr1 gene, is one of the ABC transporters held responsible for the phenomenon of multidrug resistance (mdr), which is reflected by a rapidly escalating failure of chemotherapy with different classes of cytotoxic agents: anthracyclins, vinca alkaloids, taxanes, epipodophylotoxins. Although overcoming resistance conveyed by Pgp alone may not be sufficient for reaching effective treatment, the abundance of observations available for this paradigmatic multidrug transporter at both in vitro and in vivo setting is a tempting ground for an updated assessment of the main currents of mdr research. In this review we attempt to help keep track of the features of Pgp-mediated drug transport that serve as the major starting points for ongoing efforts of mdr reversal. We will analyze the slowly narrowing gaps that prevail between our ever increasing understanding at the protein, cell and organism level, focusing on the molecular interactions involving Pgp.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Algorithms Alkaloids Amino Acids analysis anthracycline Antibodies antineoplastic activity Antineoplastic Agents Apoptosis Ascites beta cyclodextrin derivative beta methylcyclodextrin binding affinity binding site Biological Transport Biophysics blood Brain cancer chemotherapy cancer resistance Capillaries Caveolae Cell Membrane Cells ceramide chemistry Cho Cells Cholesterol Cloning,Molecular colchicine concentration response cyclodextrin derivative cyclosporin A Daunorubicin Dexamethasone Dna doxorubicin drug binding drug distribution drug effect Drug Interactions drug potentiation Drug Resistance Drug Resistance,Multiple drug transport drug treatment failure drug uptake Enzymes Epitopes Fluorescence Fluorescence correlation spectroscopy Genes,MDR glycoprotein P histone deacetylase inhibitor Hiv Hiv-1 Homeostasis Human human cell Humans Hungary Hydrolysis Hydrophobicity hydroxymethylglutaryl coenzyme A reductase inhibitor In Vitro Ivermectin Kinetics Light lipid composition lipid raft Lipids Membrane Microdomains membrane permeability Membrane Proteins metabolism methods Mice Microscopy Models,Genetic Molecular Biology molecular interaction monoclonal antibody monoclonal antibody uic2 mouse Multidrug resistance Mutation Neoplasms nicardipine nonhuman Ovary P-Glycoprotein Paclitaxel Peptides Permeability pharmacokinetics pharmacology Phospholipids physiology Proteins Research review Rhodamine 123 Signal Transduction Sphingosine sphingosine 1 phosphate Substrate Specificity tariquidar taxane derivative Temperature therapy toxicity trends unclassified drug Valinomycin valspodar Verapamil Vinblastine Vinca alkaloid vincristine Water Xenopus
Megjelenés:	Current Cancer Drug Targets. - 9 : 3 (2009), p. 281-297. -
További szerzők:	Bacsó Zsolt (1963-) (biofizikus) Szabó Gábor (1953-) (biofizikus)
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat DOI
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