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001-es BibID:
BIBFORM010427
Első szerző:
Steinbeck, Gerhard
Cím:
Defibrillator implantation early after myocardial infarction / Gerhard Steinbeck, Dietrich Andresen, Karlheinz Seidl, Johannes Brachmann, Ellen Hoffmann, Dariusz Wojciechowski, Zdzislawa Kornacewicz-Jach, Beata Sredniawa, Géza Lupkovics, Franz Hofgärtner, Andrzej Lubinski, Marten Rosenqvist, Alphonsus Habets, Karl Wegscheider, Jochen Senges, The IRIS Investigators
Dátum:
2009
ISSN:
0028-4793 (Print)
Megjegyzések:
The rate of death, including sudden cardiac death, is highest early after a myocardial infarction. Yet current guidelines do not recommend the use of an implantable cardioverter-defibrillator (ICD) within 40 days after a myocardial infarction for the prevention of sudden cardiac death. We tested the hypothesis that patients at increased risk who are treated early with an ICD will live longer than those who receive optimal medical therapy alone. METHODS: This randomized, prospective, open-label, investigator-initiated, multicenter trial registered 62,944 unselected patients with myocardial infarction. Of this total, 898 patients were enrolled 5 to 31 days after the event if they met certain clinical criteria: a reduced left ventricular ejection fraction (< or = 40%) and a heart rate of 90 or more beats per minute on the first available electrocardiogram (ECG) (criterion 1: 602 patients), nonsustained ventricular tachycardia (> or = 150 beats per minute) during Holter monitoring (criterion 2: 208 patients), or both criteria (88 patients). Of the 898 patients, 445 were randomly assigned to treatment with an ICD and 453 to medical therapy alone. RESULTS: During a mean follow-up of 37 months, 233 patients died: 116 patients in the ICD group and 117 patients in the control group. Overall mortality was not reduced in the ICD group (hazard ratio, 1.04; 95% confidence interval [CI], 0.81 to 1.35; P=0.78). There were fewer sudden cardiac deaths in the ICD group than in the control group (27 vs. 60; hazard ratio, 0.55; 95% CI, 0.31 to 1.00; P=0.049), but the number of nonsudden cardiac deaths was higher (68 vs. 39; hazard ratio, 1.92; 95% CI, 1.29 to 2.84; P=0.001). Hazard ratios were similar among the three groups of patients categorized according to the enrollment criteria they met (criterion 1, criterion 2, or both). CONCLUSIONS: Prophylactic ICD therapy did not reduce overall mortality among patients with acute myocardial infarction and clinical features that placed them at increased risk.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Aged
Cause of Death
Death, Sudden, Cardiac
control
Defibrillators, Implantable
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction
Proportional Hazards Models
Registries
Risk
Survival Rate
Time Factors
Megjelenés:
The New England Journal of Medicine. - 361 : 15 (2009), p. 1427-1436. -
További szerzők:
Andresen, Dietrich
Seidl, Karlheinz
Brachmann, Johannes
Hoffmann, Ellen
Wojciechowski, Dariusz
Kornacewicz-Jach, Zdzislawa
Sredniawa, Beata
Lupkovics Géza
Hofgärtner, Franz
Lubinski, Andrzej
Rosenqvist, Marten
Habets, Alphonsus
Wegscheider, Karl
Senges, Jochen
Édes István (1952-) (kardiológus)
Kolozsvári Rudolf (1976-) (kardiológus)
The IRIS Investigators
Internet cím:
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