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001-es BibID:	BIBFORM010428
Első szerző:	Tardif, Jean-Claude
Cím:	Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy : a 4-month, randomized, placebo-controlled trial / Jean-Claude Tardif, Piotr Ponikowski, Thomas Kahan, The ASSOCIATE Study Investigators
Dátum:	2009
ISSN:	0195-668X (Print)
Megjegyzések:	To evaluate the anti-anginal and anti-ischaemic efficacy of the selective I(f) current inhibitor ivabradine in patients with chronic stable angina pectoris receiving beta-blocker therapy. METHODS AND RESULTS: In this double-blinded trial, 889 patients with stable angina receiving atenolol 50 mg/day were randomized to receive ivabradine 5 mg b.i.d. for 2 months, increased to 7.5 mg b.i.d. for a further 2 months, or placebo. Patients underwent treadmill exercise tests at the trough of drug activity using the standard Bruce protocol for randomization and at 2 and 4 months. Total exercise duration at 4 months increased by 24.3 +/- 65.3 s in the ivabradine group, compared with 7.7 +/- 63.8 s with placebo (P < 0.001). Ivabradine was superior to placebo for all exercise test criteria at 4 months (P < 0.001 for all) and 2 months (P-values between <0.001 and 0.018). Ivabradine in combination with atenolol was well tolerated. Only 1.1% of patients withdrew owing to sinus bradycardia in the ivabradine group. CONCLUSION: The combination of ivabradine 7.5 mg b.i.d. and atenolol at the commonly used dosage in clinical practice in patients with chronic stable angina pectoris produced additional efficacy with no untoward effect on safety or tolerability.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adrenergic beta-Antagonists Adult Aged Angina Pectoris Atenolol Benzazepines Blood Pressure Cardiovascular Agents Double-Blind Method Drug Therapy, Combination Exercise Test Exercise Tolerance Female Heart Rate Humans Ion Channels Male Middle Aged Sinoatrial Node Treatment Outcome Young Adult
Megjelenés:	European Heart Journal. - 30 : 5 (2009), p. 540-548. -
További szerzők:	Ponikowski, Piotr Kahan, Thomas Édes István (1952-) (kardiológus) The ASSOCIATE Study Investigators
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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