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001-es BibID:	BIBFORM010541
Első szerző:	Tircsó Gyula (vegyész, kémia tanár)
Cím:	(S)-5-(p-Nitrobenzyl)-PCTA, a Promising Bifunctional Ligand with Advantageous Metal Ion Complexation Kinetics / Gyula Tircsó, Enikő Tircsóné Benyó, Eul Hyun Suh, Paul Jurek, Garry E. Kiefer, A. Dean Sherry, Zoltán Kovács
Dátum:	2009
ISSN:	1043-1802
Megjegyzések:	A bifunctional version of PCTA (3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9,-tria cetic acid) that exhibits fast complexation kinetics with the trivalent lanthanide(III) ions was synthesized in reasonable yields starting from N,N',N"-tristosyl-(S)-2-(p-nitrobenzyl)-diethylenetriamine. pH-potentiometric studies showed that the basicities of p-nitrobenzyl-PCTA and the parent ligand PCTA were similar. The stability of M(NO2-BnPCTA) (M = Mg2+ Ca2+, Cu2+, Zn2+) complexes was similar to that of the corresponding PCTA complexes, while the stability of Ln(3+) complexes of the bifunctional ligand is somewhat lower than that of PCTA chelates. The rate of complex formation of Ln(NO2-Bn-PCTA) complexes was found to be quite similar to that of PCTA, a ligand known to exhibit the fastest formation rates among all lanthanide macrocyclic ligand complexes studied to date. The acid-catalyzed decomplexation kinetic studies of the selected Ln(NO2-Bn-PCTA) complexes showed that the kinetic inertness of the complexes was comparable to that of Ln(DOTA) chelates making the bifunctional ligand NO2-Bn-PCTA suitable for labeling biological vectors with radioisotopes for nuclear medicine applications.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Bioconjugate Chemistry. - 20 :3 (2009), p. 565-575. -
További szerzők:	Tircsóné Benyó Enikő (1977-) (vegyész, kémia tanár) Suh, Eul Hyun Jurek, Paul Kiefer, Garry E. Sherry, A. Dean Kovács Zoltán
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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