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001-es BibID:BIBFORM010557
Első szerző:Sairanen, Tiina
Cím:Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke / Tiina Sairanen, Rita Szepesi, Marja Liisa Karjalainen-Lindsberg, Jani Saksi, Anders Paetau, Perttu J. Lindsberg
Dátum:2009
ISSN:0001-6322 (Print)
Megjegyzések:Apoptotic cell death contributes to neuronal loss in the penumbral region of brain infarction. Activated caspase-3 (ACA-3) cleaves proteins including poly ADPribose) polymerase-1 (PARP-1) important in DNA repair, thus promoting apoptosis. Overactivation of PARP-1 depletes NAD? and ATP, resulting in necrosis. These cell death phenomena have been investigated mostly in experimental animals. We studied an autopsy cohort of 13 fatal ischemic stroke cases (symptoms 15 h to 18 days) and 2 controls by immunohistochemical techniques. The number of PARP-1 immunoreactive neurons was highest in the periinfarct area. Nuclear PARP-1 correlated with increasing neuronal necrosis (P = 0.013). Cytoplasmic PARP-1 correlated with TUNEL in periinfarct and core areas (P = 0.01). Cytoplasmic cleaved PARP-1 was inversely correlated with increasing necrotic damage (P = 0.001). PAR-polymers were detected in neurons confirming enzymatic activity of PARP-1. Cytoplasmic ACA-3 correlated with death receptor Fas (rs = 0.48; P = 0.005). In conclusion, the confirmation of the same pathways of cell death than previously described in experimental animal models encourages neuroprotective treatments acting on these mediators also in human stroke.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ischemic stroke
Apoptosis
Human
PARP-1
Caspase-3
mmunohistochemistry
Megjelenés:Acta Neuropathologica. - 118 : 4 (2009), p. 541-552. -
További szerzők:Szepesi Rita (1975-) (neurológus) Karjalainen-Lindsberg, Marja Liisa Saksi, Jani Paetau, Anders Lindsberg, Perttu J.
Internet cím:DOI
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