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001-es BibID:	BIBFORM010927
Első szerző:	Szamosi Tamás
Cím:	Early azathioprine/biological therapy is associated with decreased risk for surgery and delays time to surgery but not reoperation in both smokers and nonsmokers with Crohn's disease, while smoking decreases the risk of colectomy in ulcerative colitis / Tamas Szamosi, Janos Banai, Laszlo Lakatos, Zsofia Czegledi, Gyula David, Ferenc Zsigmond, Tunde Pandur, Zsuzsanna Erdelyi, Orsolya Gemela, Maria Papp, Janos Papp, Peter Laszlo Lakatos
Dátum:	2010
ISSN:	0954-691X (Print)
Megjegyzések:	Smoking may alter the natural course of Crohn's disease (CD). Smokers are more likely to develop complications, relapses and have a greater risk for surgery. In contrast, in ulcerative colitis (UC), smoking might improve the disease course. Our aim was to assess the combined effect of disease phenotype, smoking, and immunomodulator [azathioprine (AZA), AZA/biological] treatment on the risk of intestinal resection/reoperation in CD and colectomy in UC. PATIENTS/METHODS: Six hundred and eighty-one inflammatory bowel disease patients were analyzed (CD: 340, male/female: 155/185, duration: 9.4+/-7.5 years; UC: 341, male/female: 174/164, duration: 11.5+/-9.7 years). Patients were interviewed on their smoking habits at the time of diagnosis and during the regular follow-up visits. Medical records were retrospectively analyzed. RESULTS: Smoking was present in 45.5% in CD and 15.8% in UC. CD patients who underwent at least one bowel resection comprised 46.5%. In an univariate analysis, disease location, behavior, AZA, or AZA/biological use before surgery [odds ratio (OR): 0.26 and 0.22, P<0.001] and smoking (OR: 1.61, P = 0.03) were associated with risk for first surgery. Smoking, AZA, or AZA/biological (P<0.001) use before first surgery and disease behavior were independently associated with risk for surgery in a proportional Cox-regression analysis. Perianal disease (OR: 3.2, P = 0.001) and frequent relapses (OR: 4.8, P<0.001) but not smoking, AZA, or AZA/biological use after first surgery were predictive for reoperation. In UC, the rate of colectomy was 5.6%. Disease location (P = 0.001) and smoking status (P = 0.02) were independently associated with risk for colectomy in a proportional Cox-regression analysis. CONCLUSION: Our data suggest that early AZA/biological therapy reduces the risk for first operation but not reoperation in CD, in both smokers and nonsmokers. In contrast, smoking was associated with a decreased need for colectomy in UC.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	European Journal of Gastroenterology and Hepatology 22 : 7 (2010), p. 872-879. -
További szerzők:	Banai János Lakatos László (orvos Budapest) Czeglédi Zsófia Dávid Gyula Zsigmond Ferenc Pandúr Tünde Erdélyi Zsuzsanna Gemela Orsolya Papp Mária (1975-) (belgyógyász, gasztroenterológus) Papp János (orvos Veszprém) Lakatos Péter (Semmelweis Egyetem)
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