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001-es BibID:	BIBFORM013841
Első szerző:	Nagy Szakál Dorottya
Cím:	Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease / Dorottya Nagy Szakál, Hajnalka Győrffy, András Arató, Áron Cseh, Kriszta Molnár, Mária Papp, Antal Dezsőfi, Gábor Veres
Dátum:	2010
Megjegyzések:	Duodenal biopsy is an important tool to diagnose coeliac disease (CD); however, the most reliable location ofbiopsy site is still questionable. Claudins (CLDNs),members of a large family of adherent junction proteins,show characteristic expression pattern in inflammatorydisorders; nevertheless, CLDN expression in CD is unknown.This is a comparative study to examine the CLDN 2, 3 and 4 expressions in proximal and distal part of duodenum in children with CD and in controls. Thirty-three children with newly diagnosed CD were enrolled. Fourteen healthy children served as controls. Biopsies from proximal and distal part of duodenum were taken for routine histological analysis. Immunohistochemistry were used todetect CD3+ intraepithelial lymphocytes and CLDN 2, 3and 4 protein expressions. Macroscopic picture, routinehistology and Marsh grade depicted no differences betweenbiopsies taken from proximal or distal part of duodenum.However, CLDN 2 expression was significantly increasedin severe form of coeliac disease in bulb and in distalduodenum, and in distal part of non-severe coeliac patients, in comparison to controls. Similar association was found concerning CLDN 3 expression. Expression of CLDN 4 was similar in all groups studied. Both proximal and distal mucosal duodenal biopsies are suitable for diagnosing villous atrophy in patients with CD. Increased expressions of CLDN 2 and 3 suggest structural changes of tight junction in coeliac disease which may be, at least in part, responsible for increased permeability and proliferation observed in coeliac disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Claudin Immunohistochemistry Duodenum Biopsy Coeliac disease egyetemen (Magyarországon) készült közlemény
Megjelenés:	Virchows Archiv. - 456 : 3 (2010), p. 245-250. -
További szerzők:	Győrffy Hajnalka Arató András Cseh Áron Molnár Kriszta Papp Mária (1975-) (belgyógyász, gasztroenterológus) Dezsőfi Antal Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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