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001-es BibID:	BIBFORM014257
Első szerző:	Faro, R.
Cím:	Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor / Faro, R., Toyoda, Y., McCully, J. D., Jagtap, P., Szabo, E., Virag, L., Bianchi, C., Levitsky, S., Szabo, C., Sellke, F. W.
Dátum:	2002
ISSN:	0003-4975 (Print)
Megjegyzések:	The activation of poly (ADP-ribose) synthetase plays an important role in the pathogenesis leading to myocardial ischemia-reperfusion injury. The aim of this study was to determine if a novel potent inhibitor of poly (ADP-ribose) synthetase, PJ34, provides myocardial protection. METHODS: Pigs were subjected to 60 minutes of regional ischemia followed by 180 minutes of reperfusion. Ten mg/kg of PJ34 (PJ34; n = 6) was administrated intravenously (treated group) from 15 to 5 minutes before reperfusion followed by 3 mg/kg/hour of PJ34 from 5 minutes before reperfusion to the end of 180 minutes reperfusion. Control pigs (n = 7) received vehicle only. Arterial and left ventricular pressure and coronary flow were monitored. RESULTS: The PJ34 showed significant reduction on infarct size (37.5%+/-4.5% and 50.5%+/-4.8% of the area at risk) for PJ34 and control pigs groups, respectively, (p < 0.05). Significant reduction in postsystolic shortening, as well as improvement on segment shortening, and positive first derivative of pressure over time (+dP/dt) maximum were also observed in PJ34 versus control pigs (p < 0.05). CONCLUSIONS: Our results suggest that PJ34 provides cardioprotection by decreasing myocardial infarct size and enhancing postischemic regional and global functional recovery.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Blood Pressure Coronary Circulation Enzyme Inhibitors Female Hemodynamics Male Myocardial Contraction Myocardial Infarction Myocardial Reperfusion Injury Myocardium külföldön készült közlemény Phenanthrenes Poly(ADP-ribose) Polymerases Swine
Megjelenés:	The Annals of Thoracic Surgery. - 73 : 2 (2002), p. 575-581. -
További szerzők:	Toyoda, Y. McCully, J. D. Jagtap, Prakash Szabó Éva (1965-) (bőrgyógyász, kozmetológus) Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Bianchi, C. Levitsky, S. Szabó Csaba Sellke, F. W.
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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