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001-es BibID:	BIBFORM014284
Első szerző:	Bai Péter (biokémikus)
Cím:	Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity / Péter Bai, Jon G. Mabley, Lucas Liaudet, László Virág, Csaba Szabó, Pál Pacher
Dátum:	2004
ISSN:	0891-5849 (Print)
Megjegyzések:	Matrix metalloproteinase (MMP) activation contributes to the development of various pathophysiological conditions, including dilated cardiomyopathy, congestive heart failure, and reperfusion injury. Increased oxidative and nitrosative stress have been implicated in the activation of MMPs and also in the cardiotoxicity of doxorubicin (DOX), a commonly used antitumor agent. Thus, we hypothesized that MMP activation occurs in DOX-induced cardiotoxicity. Male Balb/c mice received a single injection of DOX (25 mg/kg i.p.) and were sacrificed 12 h, 1, 2, 3 and 4 days later. Hearts and aortae were harvested for MMP zymography. DOX induced time-dependent activation of MMPs both in the heart and in the aortic tissue with an earlier onset in the latter. These results demonstrate that MMP activation is an early event in DOX-induced cardiotoxicity and raises the possibility that MMP inhibitors may influence the outcome of this severe complication.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Antineoplastic Agents/toxicity Biological Markers/analysis Cardiomyopathy, Dilated/chemically induced/enzymology Doxorubicin/ toxicity Enzyme Activation Heart/ drug effects Heart Failure/chemically induced Male Matrix Metalloproteinases/ metabolism0891-5849 Mice Mice, Inbred BALB C Models, Animal Myocardium/enzymology/ pathology Reperfusion Injury/chemically induced/enzymology Acute Disease Catalysis/drug effects Chronic Disease Creatine Kinase/blood Disease Models, Animal Enzyme Inhibitors/pharmacology Heart/ drug effects/physiopathology Heart Failure/ chemically induced/physiopathology/prevention & control L-Lactate Dehydrogenase/blood Metalloporphyrins/ pharmacology Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase/antagonists & inhibitors/genetics/metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Oxidative Stress/drug effects/genetics Peroxynitrous Acid/ metabolism Survival Rate Antibiotics, Antineoplastic Creatine Kinase/metabolism Doxorubicin Enzyme Activation/drug effects Heart Failure/ chemically induced/pathology/physiopathology Hemodynamics/drug effects L-Lactate Dehydrogenase/metabolism Metalloendopeptidases/metabolism Poly(ADP-ribose) Polymerases/ genetics/ metabolism Survival Analysis Ventricular Function, Left/genetics Apoptosis Benzamides/ pharmacology Caspases/metabolism Cells, Cultured DNA Damage/drug effects DNA Fragmentation/drug effects Enzyme Activation/drug effects/physiology Enzyme Inhibitors/ pharmacology Mitochondria/ drug effects Nitrates Nitrites/toxicity Nitrogen Oxides/ toxicity Poly(ADP-ribose) Polymerases/ antagonists & inhibitors/metabolism Protective Agents/ pharmacology Thymus Gland/cytology/ drug effects Tyrosine
Megjelenés:	Oncology reports. - 11 : 2 (2004), p. 505-508. -
További szerzők:	Mabley, Jon G. Liaudet, Lucas Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Szabó Csaba Pacher Pál
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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