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001-es BibID:	BIBFORM014291
Első szerző:	Huber, Aline
Cím:	PARP-1, PARP-2 and ATM in the DNA damage response : functional synergy in mouse development / Huber, A., Bai, P., de Murcia, J. M., de Murcia, G.
Dátum:	2004
ISSN:	1568-7864 (Print)
Megjegyzések:	Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a superfamily of 18 proteins, encoded by different genes and displaying a common conserved catalytic domain. PARP-1 (113kDa), the founding member, and PARP-2 (62kDa) are both involved in DNA-break sensing and signaling when single strand break repair (SSBR) or base excision repair (BER) pathways are engaged. The generation by homologous recombination of deficient mouse models have confirmed the caretaker function of PARP-1 and PARP-2 in mammalian cells under genotoxic stress. This review summarizes our present knowledge on their physiological role in the cellular response to DNA damage and on the genetic interactions between PARP-1, PARP-2, Atm that play an essential role during early embryogenesis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Catalytic Domain Cell Cycle Proteins Cell Proliferation DNA Damage DNA Repair DNA-Binding Proteins Gene Expression Regulation, Developmental Heterozygote Histones/metabolism Humans Mice Models, Biological Oxidative Stress Poly(ADP-ribose) Polymerases/metabolism/ physiology Protein-Serine-Threonine Kinases/metabolism/ physiology Signal Transduction Tumor Suppressor Proteins
Megjelenés:	DNA Repair. - 3 : 8-9 (2004), p. 1103-1108. -
További szerzők:	Bai Péter (1976-) (biokémikus) de Murcia, Josiane Ménissier de Murcia, Gilbert
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus változat DOI
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