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001-es BibID:	BIBFORM015604
035-os BibID:	15778910
Első szerző:	Schulte-Altedorneburg, Gernot
Cím:	Measuring carotid artery stenosis-comparison of postmortem arteriograms with theplanimetric gold standard / Schulte-Altedorneburg Gernot, Droste Dirk W., Kollar Jozef, Beyna Torsten, Felszeghy Szabolcs, Modis Laszlo, Hegedus Csaba, Ringelstein E. Bernd, Csiba Laszlo
Dátum:	2005
ISSN:	0340-5354 (Linking)
Megjegyzések:	Five different calliper methods for assessing the degree of carotidartery stenosis and visual estimation ("eyeballing") of postmortem carotidarteriograms were compared with the planimetric gold standard of the areareduction at the site of the stenosis. METHODS: During autopsy 53 carotidspecimens were removed in toto from 31 neurological patients. Carotid arterieswere ligated and redistended to a physiological degree for standardisedthree-plane arteriography. Afterwards, the entire specimen was filled with anembedding medium under the same conditions and sectioned. Slices at the site ofstenoses were histologically processed. Computerised planimetric analysis of thelumen area reduction was performed and compared with the arteriographic findings.Arteriograms were evaluated by two independent observers by means of linearCommon Carotid Artery (CC), the European Carotid Surgery Trial (ECST) and theNorth American Symptomatic Carotid Endarterectomy Trial (NASCET), and squaredmeasurements (NASCET2, ECST2) after applying the pi r2 function. Further, threeindependent observers performed eyeballing of the degree of stenosis from thepostmortem arteriographies. RESULTS: Planimetry was carried out in 29 internalcarotid artery (ICA) and 17 common carotid artery (CCA) stenoses ranging from 8.5to 100%. The smallest mean differences of the degree of stenosis in % betweenplanimetry and arteriography were -0.5 and 0.6%. The narrowest 95 %-limits ofagreement covered a range of +/-24.1 and 26.3% of stenoses, and the highestcorrelation coefficients were both 0.9 for the CC and ECST2 techniques,respectively. By eyeballing, the degree of stenosis was underestimated by 13.5 to15.8% on average. The narrowest limits of agreement between two observers foreyeballing covered a range of 35%. CONCLUSION: Three-plane arteriography has onlya moderate accuracy and reproducibility in detecting and measuring carotid arterystenosis independent of the technique of measurement used.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Aged Angiography/methods Carotid Artery, Common/pathology/radiography Carotid Artery, External/pathology/radiography Carotid Artery, Internal/pathology/radiography Carotid Stenosis/pathology/radiography Female Humans egyetemen (Magyarországon) készült közlemény Male
Megjelenés:	The Journal of Neurology. - 252 : 5 (2005), p. 575-582. -
További szerzők:	Droste, Dirk W. Kollár József (1950-) (radiológus) Beyna, Torsten Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Módis László (1939-) (anatómus, kötőszövetbiológus) Hegedűs Csaba (1953-) (fogszakorvos) Ringelstein, E. Bernd Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI elektronikus változat
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