Találati lista | Tudóstér

001-es BibID:	BIBFORM015626
Első szerző:	Székvölgyi Lóránt (biofizikus, biokémikus, sejtbiológus)
Cím:	From meiosis to postmeiotic events: Homologous recombination is obligatory but flexible / Szekvolgyi, L., Nicolas, A.
Dátum:	2010
Megjegyzések:	Sexual reproduction depends on the success of faithful chromosome transmission during meiosis to yield viable gametes. Central to meiosis is the process of recombination between paternal and maternal chromosomes, which boosts the genetic diversity of progeny and ensures normal homologous chromosome segregation. Imperfections in meiotic recombination are the source of de novo germline mutations, abnormal gametes, and infertility. Thus, not surprisingly, cells have developed a variety of mechanisms and tight controls to ensure sufficient and well-distributed recombination events within their genomes, the details of which remain to be fully elucidated. Local and genome-wide studies of normal and genetically engineered cells have uncovered a remarkable stochasticity in the number and positioning of recombination events per chromosome and per cell, which reveals an impressive level of flexibility. In this minireview, we summarize our contemporary understanding of meiotic recombination and its control mechanisms, and address the seemingly paradoxical and poorly understood diversity of recombination sites. Flexibility in the distribution of meiotic recombination events within genomes may reside in regulation at the chromatin level, with histone modifications playing a recently recognized role
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban BUDDING YEAST Cells Chromatin Chromosomes double-strand break DOUBLE-STRAND-BREAK Genome histone modification HOLLIDAY JUNCTION RESOLVASE HOT-SPOTS Infertility INITIATION SITES MEIOTIC GENE CONVERSION Molecular Biology Mutation PREMATURE OVARIAN FAILURE recombination review sister chromatid cohesion SISTER-CHROMATID COHESION Spo11 SYNAPTONEMAL COMPLEX-FORMATION YEAST SACCHAROMYCES-CEREVISIAE OTKA::1 MAB::3.1
Megjelenés:	The FEBS Journal. - 277 : 3 (2010), p. 571-589. -
További szerzők:	Nicolas, Alain
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus elérés DOI
Borító:
Saját polcon: