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001-es BibID:	BIBFORM015746
Első szerző:	Machackova, Jarmila
Cím:	Myofibrillar remodelling in cardiac hypertrophy, heart failure and cardiomyopathies / Jarmila Machackova, Barta Judit, Naranjan S. Dhalla
Dátum:	2006
Megjegyzések:	A wide variety of pathological conditions havebeen shown to result in cardiac remodelling and myocardial dysfunction. However, the mechanisms of transition from adaptive to maladaptive alterations, as well as those for changes in cardiac performance leading to heart failure, are poorly understood. OBSERVATIONS: Extensive studies have revealed a broad spectrum of progressive changes in subcellular structures and function, as well asin signal transduction and metabolism in the heart, among different cardiovascular disorders. The present review is focused on identifying the alterations in molecular and biochemical structure of myofibrils (myofibrillar remodelling) in hypertrophied and failing myocardiumin different types of heart diseases. Numerous changes at the level of gene expression for both contractile and regulatory proteins have already been reported in failing hearts and heart diseases; these changes are potential precursors for heart failure such as cardiac hypertrophyand cardiomyopathies. Myofibrillar remodelling, as a consequence of proteolysis, oxidation, and phosphorylation of some functional groups in both contractile and regulatory proteins in hearts failing due to different etiologies, has also been described. CONCLUSIONS: Although myofibrillar remodelling appears to be associated with cardiac dysfunction, alterations in both contractileand regulatory proteins are dependent on the type and stage of heart disease.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cardiac gene expression Cardiomyopathies Congestive heart failure Myocardial infarction Myofibrillar alterations
Megjelenés:	The Canadian Journal of Cardiology. - 22 : 11 (2006), p. 953-968. -
További szerzők:	Barta Judit (1975-) (kardiológus) Dhalla, Naranjan S.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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