Találati lista | Tudóstér

001-es BibID:	BIBFORM015796
Első szerző:	Bálint Géza
Cím:	Ex vivo soft-laser treatment inhibits the synovial expression of vimentin and {alpha}-enolase, potential autoantigens in rheumatoid arthritis / Géza Bálint, Klára Barabás, Zsuzsanna Zeitler, József Bakos, Katalin A. Kékesi, Ákos Pethes, Erzsébet Nagy, Tamás Lakatos, Péter V. Bálint, Zoltán Szekanecz
Dátum:	2011
ISSN:	1538-6724 (Electronic)
Megjegyzések:	Soft-laser therapy has been used to treat rheumatic diseases for decades. The major effects of laser treatment may be dependent not on thermal mechanisms but rather on cellular, photochemical mechanisms. However, the exact cellular and molecular mechanisms of action have not been elucidated. Objective The aim of this study was to investigate the ex vivo effects of low-level laser treatment (with physical parameters similar to those applied previously) on protein expression in the synovial membrane in rheumatoid arthritis (RA). Design Synovial tissues were laser irradiated, and protein expression was analyzed. METHODS:/b> Synovial membrane samples obtained from 5 people who had RA and were undergoing knee surgery were irradiated with a near-infrared diode laser at a dose of 25 J/cm(2) (a dose used in clinical practice). Untreated synovial membrane samples obtained from the same people served as controls. Synovial protein expression was assessed with 2-dimensional polyacrylamide gel electrophoresis followed by mass spectrometry. RESULTS: /b> The expression of 12 proteins after laser irradiation was different from that in untreated controls. Laser treatment resulted in the decreased expression of alpha-enolase in 2 samples and of vimentin and precursors of haptoglobin and complement component 3 in 4 samples. The expression of other proteins, including 70-kDa heat shock protein, 96-kDa heat shock protein, lumican, osteoglycin, and ferritin, increased after laser therapy. Limitations The relatively small sample size was a limitation of the study. CONCLUSIONS:/b> Laser irradiation (with physical parameters similar to those used previously) resulted in decreases in both alpha-enolase and vimentin expression in the synovial membrane in RA. Both proteins have been considered to be important autoantigens that are readily citrullinated and drive autoimmunity in RA. Other proteins that are expressed differently also may be implicated in the pathogenesis of RA. Our results raise the possibility that low-level laser treatment of joints affected with RA may be effective, at least in part, by suppressing the expression of autoantigens. Further studies are needed.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Physical Therapy. -
További szerzők:	Barabás Klára Zeitler Zsuzsanna Bakos József (gyógyszerész) Kékesi Katalin Adrienna Pethes Ákos Nagy Erzsébet (orvos, Budapest) Lakatos Tamás Bálint Péter V. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	DOI elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: