Találati lista | Tudóstér

001-es BibID:	BIBFORM016000
Első szerző:	Hargitai Dóra
Cím:	Calcium entry is regulated by Zn2+ in relation to extracellular ionic environment in human airway epithelial cells / Hargitai, D., Pataki, A., Raffai, G., Fuzi, M., Danko, T., Csernoch, L., Varnai, P., Szigeti, G. P., Zsembery, A.
Dátum:	2010
ISSN:	1569-9048
Megjegyzések:	The extracellular pH, sodium and divalent cation concentrations influence the ATP-induced changes in cytosolic Ca2+ concentration ([Ca2+](i)). This elevation of [Ca2+](i) and activation of Ca2+-dependent Cl- channels represent a possible therapeutic approach in cystic fibrosis (CF). We investigated the changes of [Ca2+](i) in different external ionic environment, and P2X purinergic receptors (P2XRs) expression in the control and CF airway epithelial cells. The parallel removal of Na+ and alkalinization of the extracellular solution increased the amplitude of sustained ATP-induced Ca2+ signals independent of wild-type or mutant CFTR expression. The ATP-induced Ca2+ entry was either inhibited or stimulated by Zn2+ depending on the extracellular Na+ concentration. In Na+-free environment, Zn2+ and other divalent cations elicited a biphasic Ca2+ signal. Immunohistochemical data suggest that, multiple subtypes of P2XRs are expressed in these airway epithelial cells. In conclusion, Ca2+ entry is finely regulated by external ionic environment. Therefore. we speculate that properly compiled aerosols could influence efficacy of zinc-based therapy in CF. (C) 2009 Elsevier B.V. All rights reserved.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Respiratory Physiology & Neurobiology. - 170 : 1 (2010), p. 67-75. -
További szerzők:	Pataki Ágnes Raffai Gábor Füzi Márta (1980-) (élettanász) Danko Tamás Csernoch László (1961-) (élettanász) Várnai Péter Szigeti Gyula (1969-) (élettanász, elektrofiziológus) Zsembery Ákos
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: