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001-es BibID:	BIBFORM016454
Első szerző:	Baranyai Zsolt (vegyész)
Cím:	Equilibrium Studies on the Gd3+, Cu2+ and Zn2+ Complexes of BOPTA, DTPA and DTPA-BMA Ligands: Kinetics of Metal-Exchange Reactions of Gd(BOPTA) (2-) / Zsolt Baranyai, Zoltán Pálinkás, Fulvio Uggeri, Ernő Brücher
Dátum:	2010
ISSN:	1434-1948
Megjegyzések:	The stability and protonation constants of the complexes formed between the ligand BOPTA [H(5)BOPTA: 4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatrideca n-13-oic acid] and Gd3+, Cu2+, and Zn2+ have been determined by pH potentiometry (Gd3+, Zn2+) and spectrophotometry (Cu2+) at 25 degrees C and at constant ionic strength maintained by 0.15 M NaCl. For comparison, the stability and protonation constants of the complexes of Gd3+, Cu2+, and Zn2+ formed with DTPA and DTPA-BMA {H(5)DTPA: diethylenetriamine-N,N,N',N '',N ''-pentaacetic acid, H(3)DTPA-BMA: 2,2'-[(carboxymethyl)imino]bis[ethylenebis(methylcarbamoyl-methyl)imino] diacetic acid} have also been determined under similar conditions. The stability constants (log K-ML) of the complexes of BOPTA and DTPA are very similar, but in 0.15 m NaCl the protonation constants of the ligands (log K-j(H)) and the log K-ML values are lower than those obtained in 0.1 M KCl or Me4NCl by 0.3-0.9 log K units. The order of selectivity of the ligands for Gd3+ over Zn2+ is BOPTA > DTPA > DTPA-BMA. The complex [Cu(DTPA-BMA)](-) deprotonates in the pH range 7-10 with the dissociation of an amide NH group and the coordination of the amide N atom. The kinetics of the exchange/transmetallation reactions between the complex [Gd(BOPTA)](2-) and the metal ions Cu2+, Zn2+, and Eu3+ have been studied by spectrophotometry (Cu2+, Eu3+) and relaxometry (Zn2+) in the pH range 3.3-6 at 25 degrees C in 0.15 m NaCl. The reactions with Cu2+ and Zn2+ occur predominantly with direct attack of the metal ions on the [Gd(BOPTA)](2-) complex. The kinetic activity of Eu3+ is lower, and in the exchange reactions with Eu3+ the proton-assisted dissociation of [Gd(BOPTA)](2-) (which is followed by fast reaction between the free ligand and Eu3+) could be also investigated. The rate constants, characterizing the proton-assisted dissociation of [Gd(BOPTA)](2-) and the exchange reactions occurring with the direct attack of Cu2+, Zn2+, and Eu3+ on the complex, are lower by about 30-90% than the rate constants obtained earlier for similar transmetallation reactions of [Gd(DTPA)](2-). The half-time for the dissociation of [Gd(BOPTA)](2-) at pH 7.4 and at 25 degrees C in the presence of 1 x 10(-5) m Zn2+ and 1 x 10(-5) M Cu2+ is 169 h.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Lanthanides Thermodynamics Kinetics Reaction mechanisms mri contrast agents diethylenetriaminepentaacetic acid stability ions dissociation dimeglumine constants biodistribution thermodynamics gadopentetate
Megjelenés:	European Journal of Inorganic Chemistry. - 13 (2010), p. 1948-1956. -
További szerzők:	Pálinkás Zoltán (1984-) (vegyész) Uggeri, Fulvio Brücher Ernő (1935-) (vegyész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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