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001-es BibID:	BIBFORM016459
Első szerző:	Csapó Edit (vegyész)
Cím:	Syntheses and characterization of Cu2+, Ni2+ and Zn2+ binding capability of histidinehydroxamic acid derivatives / Edit Csapó, Péter Buglyó, Nóra Veronika Nagy, M. Amélia Santos, Alma Coronad, Etelka Farkas
Dátum:	2010
ISSN:	0277-5387
Megjegyzések:	Two histidinehydroxamic acid derivatives (N-methyl-histidinehydroxamic acid, N-Me-Hisha and Z-histidinehydroxamic acid, Z-Hisha) have been synthesized and their complexation with Cu2+-, Ni2+- and Zn2+-ions has been studied by using pH-potentiometric, UV-Vis, CD, H-1 NMR, EPR and ESI-MS methods. Both of the two new derivatives contain one donor atom less compared to the histidinehydroxamic acid (Hisha). In the case of N-Me-Hisha the hydroxamate-N as donor is eliminated, while the coordination of the amino-N of Z-Hisha is not possible at all. With the ambidentate N-Me-Hisha, the histamine-type coordination mode is favoured if the metal ion is Ni2+ and the bis-[NH2,N-imid] complex is the most stable in this system. The mixed type, [NH2,N-imid] + [O,O], coordination mode dominates in the Cu2+- N-Me-Hisha complexes, while different low stability mono-chelated linkage isomers are formed with Zn2+. With Z-Hisha (having poor water solubility) hydroxamate-type coordination mode predominates in low stability complexes in the Ni2+ and Zn2+ containing systems. Interestingly, the interaction with Cu2+ is very strong and results in the formation of a high stability 12-MC-4 type metallacrown with involvement of 5-membered and 7-membered chelates. (C) 2010 Elsevier Ltd. All rights reserved.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Histidinehydroxamic acid derivatives Cu2+-, Ni2+-, Zn2+-complexes Solution equilibrium Potential metalloenzyme inhibitors matrix-metalloproteinase inhibitors mixed-ligand complexes aqueous-solution hydroxamic acids aminohydroxamic acids copper(ii) complexes methioninehydroxamic acids dissociation-constants metal complexation coordination
Megjelenés:	Polyhedron. - 29 : 16 (2010), p. 3137-3145. -
További szerzők:	Buglyó Péter (1965-) (vegyész) Nagy Nóra Veronika Santos, Amélia M. Corona, Alma Farkas Etelka (1948-) (vegyész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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