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001-es BibID:	BIBFORM016679
Első szerző:	Nagy Béla Jr. (labordiagnosztikai szakorvos)
Cím:	Platelet-derived microparticle levels are significantly elevated in patients treated by elective stenting compared to subjects with diagnostic catheterization alone / Nagy Béla, Szűk Tibor, Beke Debreceni Ildikó , Kappelmayer János
Dátum:	2010
ISSN:	0953-7104
Megjegyzések:	Significant platelet reactivity with endothelial damage may occur during percutaneous coronary intervention such asballoon angioplasty and elective stenting in patients with stenotic or occluded arteries in coronary artery disease. Activatedplatelets express several surface epitopes to aggregate and form heterotypic interactions with leukocytes and endothelialcells, secrete biomarkers to enhance their prothrombotic properties and also generate increased level of microparticles(PMPs). These events may contribute to subacute stent thrombosis induced by the procedure-mediated trauma. Our aimwas to study the level of PMPs and other platelet activation markers at an early time point after stenting with bare metalstent in patients on aspirin antiplatelet pre-treatment, and these results were compared to data obtained from subjects withdiagnostic catheterization alone. We found that at 15 minutes after the completion of stenting, the levels of PMPs(557!83/ml versus 325!42/ml), the platelet P-selectin expression (2.7!0.3% versus 1.99!0.1%) and the ratio ofplatelet-monocyte heterotypic aggregates (48!4% versus 38!3%) were significantly (p50.05) elevated in patientscompared to unstented subjects, but no difference was found in soluble P-selectin values. We suggest that the observedcellular changes are early and sensitive markers to detect the platelet-activating effect of stent implantation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Platelets. - 21 : 2 (2010), p. 147-151. -
További szerzők:	Szűk Tibor (1967-) (kardiológus) Bekéné Debreceni Ildikó (1970-) (biológus) Kappelmayer János (1960-) (laboratóriumi szakorvos)
Pályázati támogatás:	K75199/2008 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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