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001-es BibID:	BIBFORM016861
Első szerző:	Felföldi Nóra (vegyész)
Cím:	Synthesis of new glycosyl biuret and urea derivatives as potential glycoenzyme inhibitors / Nóra Felföldi, Marietta Tóth, Evangelia D. Chrysina, Maria-Despoina Charavgi, Kyra-Melinda Alexacou, László Somsák
Dátum:	2010
ISSN:	0008-6215
Megjegyzések:	O-Peracetylated 1-(beta-D-glucopyranosyl)-5-phenylbiuret was prepared in the reaction of O-peracetylated beta-D-glucopyranosylisocyanate and phenylurea. The reaction of O-peracetylated N-beta-D-glucopyranosylurea with phenylisocyanate furnished the corresponding 1-(beta-D-glucopyranosyl)-3,5-diphenyl- as well as 3-(beta-D-glucopyranosyl)-1,5-diphenyl biurets besides 1-(beta-D-glucopyranosyl)-3-phenylurea. O-Peracetylated 1-(beta-D-glucopyranosyl)-5-(beta-D-glycopyranosyl)biurets were obtained in one-pot reactions of O-peracetylated beta-D-glucopyranosylamine with OCNCOCl followed by a second glycopyranosylamine of beta-D-gluco, beta-D-galacto and beta-D-xylo configurations. O-Acyl protected 1-(beta-D-glucopyranosyl)-3-(beta-D-glycopyranosylcarbonyl)ureas were obtained from the reaction of beta-D-glucopyranosylisocyanate with C-(glycopyranosyl)formamides of beta-D-gluco and beta-D-galacto configurations. The O-acyl protecting groups were removed under acid- or base-catalyzed transesterification conditions, except for the N-acylurea derivatives where the cleavage of the N-acyl groups was faster than deprotection. Some of the new compounds exhibited moderate inhibition against rabbit muscle glycogen phosphorylase b and human salivary alpha-amylase.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Glycosyl urea Glycosyl biuret Inhibitor alpha-Amylase Glycogen phosphorylase
Megjelenés:	Carbohydrate Research. - 345 : 2 (2010), p. 208-213. -
További szerzők:	Tóth Marietta (1974-) (vegyész) Chrysina, Evangelia D. Charavgi, Maria-Despoina Alexacou, Kyra-Melinda Somsák László (1954-) (vegyész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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