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001-es BibID:	BIBFORM017912
Első szerző:	Mészáros T. (Budapest)
Cím:	C1-inhibitor autoantibodies in SLE. / Mészáros T., Füst G., Farkas H., Jakab L., Temesszentandrási G., Nagy G., Kiss E., Gergely P., Zeher M., Griger Z., Czirják L., Hóbor R., Haris A., Polner K., Varga L.
Dátum:	2010
ISSN:	0961-2033
Megjegyzések:	The presence of anti-C1-inhibitor (anti-C1-INH) autoantibodies is a hallmark of acquired C1-inhibitor deficiency. However, only scarce data are available on their prevalence, diagnostic value, and/or significance in systemic lupus erythematosus (SLE). In a multicentre study, we determined the levels of autoantibodies to C1-inhibitor in sera from 202 patients with SLE and 134 healthy controls. Additional clinical and laboratory parameters, such as organ involvement, as well as anti-C1q, anti-double-stranded DNA antibody, erythrocyte sedimentation rate, C-reactive protein, C3 and C4 serum complement levels have been studied in patients. The level of anti-C1-INH IgG was significantly higher (p = 0.034) in SLE patients, than in the controls. A high anti-C1-INH level of > or =0.4 U/ml (mean of controls + 2 SD) was found in 17% of the patients, but in only 4% of the controls (p = 0.0003). The SLEDAI score was significantly higher (p = 0.048) and the duration of SLE was significantly longer (p = 0.0004) among patients with elevated anti-C1-INH levels compared with patients without this autoantibody (median disease duration 8 vs. 17 years, respectively). Anti-C1-INH level was not correlated with any other laboratory parameter or organ manifestation of the disease. These findings indicate that the anti-C1-INH level is higher in SLE patients than in healthy controls and furthermore, the anti-C1-INH level correlates with the duration and activity of the disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Lupus 19 : 5 (2010), p. 634-638. -
További szerzők:	Füst György (Budapest) Farkas H. (Budapest) Jakab Lajos (Budapest) Temesszentandrási G. (Budapest) Nagy G. (Budapest) Kiss Emese (Budapest) Gergely Péter (Budapest) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Czirják László Hóbor Renáta Haris A. (Budapest) Polner Kálmán Varga L. (Budapest)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus változat DOI
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