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001-es BibID:	BIBFORM019560
Első szerző:	Aleksza Magdolna
Cím:	Increased frequency of intracellular interleukin (IL)-13 and IL-10, but not IL-4, expressing CD4+ and CD8+ peripheral T cells of patients with atopic dermatitis / M. Aleksza, B. Irinyi, A. Lukács, P. Antal-Szalmás, J. Hunyadi, A. Szegedi
Dátum:	2002
Megjegyzések:	Background A number of studies exist demonstrating the increased expression of type 2 cytokinesand decreased capacity to produce interferon-c (IFN-c) in peripheral blood mononuclear cells(PBMCs) of patients with atopic dermatitis (AD).Objectives To clarify the results of recent studies concerning the role of interleukin (IL)-4 and IL-13in PBMCs of AD patients, we analysed the activation status of lymphocyte subpopulations.Methods We measured the intracellular expression and serum levels of certain type 1 and type 2cytokines, using cell surface and intracellular cytokine staining, flow cytometry and enzyme-linkedimmunosorbent assay techniques.Results The frequency of IL-10 and IL-13 producing CD4+ and CD8+ T cells was significantlyhigher in patients with AD, while the frequency of IFN-c secreting helper and cytotoxic T cells wassignificantly lower in patients with AD than in control subjects. The serum levels of IL-10 and IL-13were also significantly increased. There were no significant differences observed between theexperimental groups in the frequency of IL-4 producing CD4+ and CD8+ cells.Conclusions This study demonstrates a type 2 cytokine production in the CD4+ and CD8+ T cellsof AD patients, which is characterized by an elevated IL-13, but not by IL-4 secretion, and by anincreased level of the immunoregulatory IL-10, which can contribute to a decrease in IFN-cexpression.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban atopic dermatitis CD4+ cells CD8+ cells flow cytometry interleukin-4 interleukin-13
Megjelenés:	British Journal of Dermatology. - 147 : 6 (2002), p. 1135-1141. -
További szerzők:	Irinyi Beatrix (1972-) (bőrgyógyász, allergológus) Lukács A. Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Szegedi Andrea (1964-) (bőrgyógyász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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