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001-es BibID:	BIBFORM020062
Első szerző:	Lee, Lester
Cím:	Germinoma with synchronous lesions in the pineal and suprasellar regions / Lester Lee, Frank Saran, Darren Hargrave, István Bódi, Sanj Bassi, Tibor Hortobágyi
Dátum:	2006
ISSN:	0256-7040
Megjegyzések:	BACKGROUND: Germinomas represent the most frequent tumour type in the pineal region and the synchronous involvement of the suprasellar region, frequently termed bifocal disease, is increasingly recognised. The incidence, pathogenesis, histomorphological, radiological, clinical features, and management strategies are discussed. CASE REPORT: A 6-year-old girl presented with clinical features of hypothalamic-pituitary axis dysfunction. MRI showed two distinct lesions in the pineal and suprasellar regions. Tumour markers for germ cell tumours from blood and cerebrospinal fluid were within the normal range. The suprasellar lesion was biopsied and the histology revealed a germinoma. She received a radical course of radiotherapy covering the entire craniospinal axis (24 Gy/15#) followed by focal boost to the sites of primary disease (16 Gy/10#). Three months after the completion of treatment, the patient achieved a complete clinical and radiological response, which was maintained during the 13-month follow-up period. CONCLUSIONS: The optimum management of primary intracranial pineal and suprasellar (bifocal) germinomas still remains controversial. The definition as either localised or disseminated disease has major implications on required treatment and its associated late morbidity. Prospective studies with large cooperative groups worldwide and consensus meetings may reduce uncertainties regarding available management options.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Child's Nervous System. - 22 : 12 (2006), p. 1513-1518. -
További szerzők:	Saran, Frank Hargrave, Darren Bódi István (1967-) (neuropatológus) Bassi, Sanj Hortobágyi Tibor (1965-) (patológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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