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001-es BibID:	BIBFORM020068
Első szerző:	Wackenfors, Angelica
Cím:	Ischemic heart disease induce upregulation of endothelin receptor mRNA in human coronary arteries / Angelica Wackenfors, Malin Emilson, Richard Ingemansson, Tibor Hortobagyi, Delia Szok, Janos Tajti, Laszlo Vecsei, Lars Edvinsson, Malin Malmsjö
Dátum:	2004
ISSN:	0014-2999
Megjegyzések:	Endothelin has been implicated in the pathogenesis of ischemic heart disease and congestive heart failure. The aims were to quantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in human coronary arteries from patients with ischemic heart disease, congestive heart failure and controls using real-time polymerase chain reaction (real-time PCR). In addition, the suitability of organ culture as a model mimicking endothelin receptor changes in cardiovascular disease was evaluated by in vitro pharmacology and real-time PCR. Endothelin ETA and ETB receptor mRNA levels were significantly higher in arteries from patients with ischemic heart disease (0.23+/-0.04 and 0.35+/-0.06) as compared to congestive heart failure (0.09+/-0.02 and 0.07+/-0.01) and controls (0.08+/-0.02 and 0.08+/-0.01). After organ culture, the endothelin ETB receptor mRNA levels were elevated, and the sarafotoxin 6c-induced vasoconstriction was more efficacious. Increased endothelin receptor activity may contribute to the increased vascular tone and development of atherosclerotic disease in ischemic heart disease in man.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Pharmacology. - 484 : 1 (2004), p. 103-109. -
További szerzők:	Emilson, Malin Ingemansson, Richard Hortobágyi Tibor (1965-) (patológus) Szok Délia Tajti János Vécsei László (1954-) (neurológus) Edvinsson, Lars Malmsjö, Malin
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