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001-es BibID:BIBFORM020073
Első szerző:Harkány Tibor
Cím:Distinct subsets of nucleus basalis neurons exhibit similar sensitivity to excitotoxicity / Tibor Harkany, Csaba Varga, Jens Grosche, Jan Mulder, Paul G. M. Luiten, Tibor Hortobágyi, Botond Penke, Wolfgang Härtig
Dátum:2002
ISSN:0959-4965
Megjegyzések:Excitotoxic lesions in the magnocellular nucleus basalis (MBN) lead to a significant damage of cholinergic neurons concomitant with increased amyloid precursor protein (APP) expression in the cerebral cortex. However, the sensitivity of non-cholinergic neurons to excitotoxicity, and changes of APP expression in the damaged MBN are still elusive. Hence, we performed multiple-labeling immunocytochemistry for choline-acetyltransferase (ChAT), neuron-specific nuclear protein (NeuN) and APP 4, 24, and 48 h after NMDA infusion in the MBN. Whereas all cholinergic neurons were immunoreactive for NeuN, this neuronal marker also labeled a population of ChAT-immunonegative non-cholinergic neurons. Both neuron populations exhibited a similar degree of sensitivity to NMDA excitotoxicity that became evident as early as 4 h post-lesion. Cholinergic MBN neurons showed abundant APP immunoreactivity (approximately 90%), while only a fraction (approximately 20-30%) of non-cholinergic neurons expressed the protein. Remarkably, cholinergic but not non-cholinergic neurons retained their APP immunoreactivity after NMDA infusion. In conclusion, cholinergic MBN neurons are not preferentially sensitive to short-term excitotoxicity, but are one of the major sources of APP in the basal forebrain.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuroreport. - 13 : 6 (2002), p. 767-772. -
További szerzők:Varga Csaba (orvos) Grosche, Jens Mulder, Jan Luiten, Paul G. M. Hortobágyi Tibor (1965-) (patológus) Penke Botond Härtig, Wolfgang
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