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001-es BibID:	BIBFORM020080
Első szerző:	Benyó Zoltán
Cím:	Neuronal nitric oxide synthase in the cerebrovascular endothelium / Zoltán Benyó, Zsombor Lacza, Tibor Hortobágyi, Christoph Görlach, Péter Sándor, Michael Wahl
Dátum:	2002
ISSN:	0531-5131
Megjegyzések:	The presence of the previous termneuronalnext term isoform of previous termnitricnext termprevious termoxidenext termprevious termsynthasenext term (nNOS) in astrocytes and neurons as well as in the perivascular nerves and previous termcerebrovascularnext termprevious termendotheliumnext term is well documented. The role of the nNOS, however, is not yet understood. In the present study, the function of previous termcerebrovascularnext term nNOS was investigated by comparing the effects of the specific nNOS blocker 7-nitro indazole monosodium salt (7-NINA) to that of the general NOS inhibitor NG-nitro-l-arginine (l-NA) in isolated rat basilar arteries (BAs). 7-NINA had no significant effect on the resting tone of the vessels, while l-NA induced strong contraction. The relaxant effect of bradykinin was attenuated in the presence of l-NA but was not changed by 7-NINA. In contrast, 7-NINA markedly reduced the acetylcholine-induced, previous termendotheliumnext term-dependent relaxation. These results demonstrate that nNOS contributes significantly to the relaxant effect of acetylcholine, indicating the functional importance of this isoenzyme in the previous termcerebrovascularnext termprevious termendotheliumnext term.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	International Congress Series. - 1235 (2002), p. 369-377. -
További szerzők:	Lacza Zsombor Hortobágyi Tibor (1965-) (patológus) Görlach, Christoph Sándor Péter (1939-) Wahl, Michael
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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