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001-es BibID:	BIBFORM021723
Első szerző:	Oláh Anna (klinikai biokémikus, vegyész)
Cím:	Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy / Oláh A. V., Asztalos L., Ivády G., Varga E., Kovács A. M., Kappelmayer J., Varga J.
Dátum:	2011
ISSN:	1434-6621
Megjegyzések:	Mycophenolic acid (MPA), a selective inhibitor of lymphocyte proliferation, has lately been used to improve renal function and prolong graft survival in renal transplanted patients. Still, there is no consensus considering the recommended dosing and the therapeutic range of MPA. Methods: To estimate the safe therapeutic range of MPA, its plasma level and indicators of kidney function were measured in 216 patients (138 male, 78 female, age 46±12 years) 67±46 months after transplantation. Besides MPA, patients received cyclosporine (Group A, n=122) or tacrolimus (Group B, n=77). Seventeen patients (Group C) were treated with MPA in combination with everolimus or sirolimus. Plasma MPA was measured by enzyme inhibition assay. Results: In the whole study group MPA level increased with the dose of MPA (p=0.013). MPA level was below the therapeutic range in 40% (Group A) and 45% (Group B) of patients, respectively. MPA was 1.9±1.56 mg/L in Group A, 2.4±1.69 mg/L in Group B. In Group A MPA level increased and cyclosporine decreased with the progress of renal disease. Conclusions: Increasing MPA/cyclosporine ratio at more severe stages of chronic kidney disease was tolerable for the patients and rejection could be avoided. Tubular damage detected by urinary N-acetyl-β-D-glucosaminidase did not correlate with the MPA level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinical Chemistry And Laboratory Medicine. - 49 : 11 (2011), p. 1849-1853. -
További szerzők:	Asztalos László (1951-) (sebész) Ivády Gergely (1979-) (laboratóriumi szakorvos) Varga Éva (1982-) (belgyógyász) Kovács M. Ágota Kappelmayer János (1960-) (laboratóriumi szakorvos) Varga József (1955-) (fizikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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