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001-es BibID:	BIBFORM024305
Első szerző:	Saukkonen, T.
Cím:	Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus / T. Saukkonen, E. Savilahti, L. Madácsy, A. Arató, A. Körner, L. Barkai, A. Sarnesto, H. K. Åkerblom
Dátum:	1996
Megjegyzések:	We investigated the association between serum antibodies to cow's milk proteins and insulin-dependent diabetes mellitus (IDDM) in Hungarian children. Forty-eight children 1.0-17.1 years of age with newly diagnosed IDDM and 74 control children 1.0-16.0 years of age were studied for serum IgG, IgA and IgM antibodies to cow's milk, ?-lactoglobulin, bovine serum albumin and ovalbumin by enzyme-linked immunosorbent assays. The specificity of IgM antibodies to ?-lactoglobulin and bovine serum albumin was controlled by Western blot. The levels of IgG and IgA antibodies to cow's milk proteins were similar in children with and without IDDM, with the exception of slightly increased levels of IgA antibodies to ?-lactoglobulin in diabetic children (P = 0.05). The levels of IgM antibodies to cow's milk were significantly higher in IDDM patients than in control children (P = 0.0002). Children with IDDM more often had IgM antibodies to ?-lactoglobulin (46.3% vs 18.8%; P = 0.002) and bovine serum albumin (87.8% vs 49.3%, P < 0.0001) than control children. Neither the levels of IgG or IgA antibodies to ovalbumin nor the frequency of IgM antibodies to ovalbumin differed between diabetic and control children. Conclusion: In Hungarian children, clinical manifestation of IDDM is often associated with IgM antibody response to cow's milk protein and bovine serum albumin, ?-lactoglobulin and bovine serum albumin, indicating a loss of immunological tolerance to these proteins. IgG and IgA antibodies to cow's milk proteins, associated with an early introduction of cow's milk in diet, seem to play a minor role in the development of childhood IDDM in Hungary.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Serum Albumin ovalbumin Milk Proteins Lactoglobulins Infant Immunoglobulin M Immunoglobulin A Hungary Humans Diabetes Mellitus, Type 1 Child, Preschool Child Adolescent priority journal milk major clinical study insulin dependent diabetes mellitus immunological tolerance immunoglobulin blood level immunoblotting human enzyme linked immunosorbent assay ARTICLE antibody titer immunoglobulin M antibody immunoglobulin A antibody beta lactoglobulin IDDM Cow's milk antibodies Bovine serum albumin antibodies ?-Lactoglobulin antibodies albumin ABSORPTION Permeability childhood RISK FINNISH CHILDREN BETA-LACTOGLOBULIN cow's milk antibodies beta-lactoglobulin antibodies
Megjelenés:	European Journal of Pediatrics. - 155 : 10 (1996), p. 885-889. -
További szerzők:	Savilahti, Erkki Madácsy László (Szeged) Arató András Körner Anna Barkai László (1958-) (gyermekgyógyász) Sarnesto, Annikki Åkerblom, H. K.
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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