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001-es BibID:	BIBFORM024336
Első szerző:	Terzano, Claudio
Cím:	Corticosteroids administered by nebulization to children with bronchial asthma / C. Terzano, L. Barkai, G. Cremonesi
Dátum:	2001
Megjegyzések:	Inhaled corticosteroids are recommended for long-term control of asthma in children, and nebulization simplifies administration to patients who lack hand-to-lung coordination. Information on the efficacy and safety of nebulized corticosteroids in children with mild to moderate asthma is limited, however, and comparison between corticosteroids is lacking. One hundred thirty-three patients 6 to 14 years of age with bronchial asthma were randomly assigned to receive flunisolide 500 ?g or budesonide 500 ?g, both administered twice daily by nebulizer for 4 weeks. Morning peak expiratory flow rate (primary efficacy endpoint) increased significantly from baseline (P<.001) with both medications (P = NS between treatments). Use of salbutamol as rescue medication decreased by 82.6% with flunisolide and by 82.7% with budesonide; respective decreases in asthma score were 78.8% and 82.3% (P<.001 vs baseline, P = NS between treatments). Only flunisolide reduced the number of nocturnal awakenings (P<.001). Ten patients in the flunisolide group and 12 in the budesonide group reported adverse events, none of which required discontinuation of treatment. In children with asthma, nebulized corticosteroids are effective and have good safety and tolerability profiles. Flunisolide and budesonide seem to produce equivalent clinical responses.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Statistics, Nonparametric Nebulizers and Vaporizers Male Humans Fluocinolone Acetonide Female Child Budesonide Asthma Anti-Inflammatory Agents Adolescent wakefulness randomized controlled trial peak expiratory flow nebulizer nebulization multicenter study major clinical study long term care human flowmeter drug tolerability drug safety drug induced disease drug efficacy disease severity controlled study controlled clinical trial clinical trial childhood disease ARTICLE soluzione salbutamol respules nisolid Flunisolide corticosteroid Nebulized drugs Inhaled corticosteroids
Megjelenés:	Advances in Therapy. - 18 : 6 (2001), p. 253-260. -
További szerzők:	Barkai László (1958-) (gyermekgyógyász) Cremonesi, G.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI Szerző által megadott URL
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