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001-es BibID:	BIBFORM024344
Első szerző:	Ságodi László
Cím:	A hyperinsulinaemia, az inzulinszerű növekedési faktor-I, inzulinszerű növekedési faktort kötő fehérje-1, a nemi hormont kötő globulin vizsgálata a prepurbertáskorú és pubertáskorú leányoknál, akiknél praematurus adrenarche lépett fel / Ságodi László, Barkai László, Tombácz Adrienn, Vámosi Ildikó
Dátum:	2003
Megjegyzések:	Precocious adrenarche is defined as the development of pubic hair before the age of 8 years in girls and 9 years in boys. Pubarche caused premature adrenarche in girls has been considered as a normal variant of pubertal development for years. Recently, it is cleared that premature pubarche can be considered as a marker of increased risk for endocrine and metabolic abnormalities. Precocious adrenarche in affected girls is associated with hyperinsulinaemia and functional ovarian hyperandrogenism during puberty. Authors investigated serum levels of insulin-like growth factor-I (IGF-I), insulin-like growth factor-binding protein-1 (IGFBP-1), insulin-like growth factor-binding protein-3 (IGFBP-3), sex hormone binding-globulin (SHBG) and levels of insulin during oral glucose tolerance test in 34 girls with premature adrenarche in 38 age- and BMI-matched healthy controls. Affected girls were assigned into prepubertal and pubertal subgroups. It has been shown that hyperinsulinaemia, decrease in IGFBP-1 and increase IGF-I levels may be present in some affected prepubertal patients. In the pubertal group, in addition to hyprinsulinaemia, decreased IGFBP-1 and increased IGF-I levels an attenuated SHBG level was observed. According to the authors, these laboratory parameters may predict endocrine and metabolic abnormalities in later life. The observed correlations support the hypothesis that insulin/IGF system plays role in the pathogenesis of hyperandrogenism in premature adrenarche and in later hormonal and metabolic changes. 12632745
Tárgyszavak:	Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban Sex Hormone-Binding Globulin puberty Male Insulin-Like Growth Factor I Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor Binding Protein 1 INSULIN hyperinsulinism hyperandrogenism Humans Female Androgens Adolescent METABOLISM human BLOOD ARTICLE somatomedin C somatomedin binding protein 3 somatomedin binding protein 1 sex hormone binding globulin androgen
Megjelenés:	Orvosi Hetilap. - 144 : 2 (2003), p. 67-72. -
További szerzők:	Barkai László (1958-) (gyermekgyógyász) Tombácz Adrienn Vámosi Ildikó
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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