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001-es BibID:	BIBFORM024349
Első szerző:	Madácsy László (Szeged)
Cím:	Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus / L. Madácsy, L. Barkai, A. Sánta, D. Krikovszky
Dátum:	2004
Megjegyzések:	Objective: The recently observed increase in the incidence of type 1 diabetes mellitus (Type 1 DM) suggests a major role of environmental factors in the etiopathogenesis of the disease. The individual variation in cytochrome P<sub>450</sub>IID6 may influence the individual susceptibility to environmentally linked diseases. We aimed to evaluate the prevalence of cytochrome P<sub>450</sub>IID6 phenotypes in Hungarian children with Type 1 DM (n = 69) compared to healthy controls (n = 100). Methods: Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine. Results: Eight of the 100 healthy subjects (8%) and 15 of the 69 diabetic children (22%) (p < 0.05) had cytochrome P<sub>450</sub>IID6 poor metabolizer phenotype (metabolic ratio ?12.6). Conclusion: Cytochrome P <sub>450</sub>IID6's activity may play a role in the development of Type 1 DM. Copyright ? 2004 S. Karger AG, Basel.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PHENOTYPE Hydroxylation Humans Diabetes Mellitus, Type 1 Debrisoquin Cytochrome P-450 CYP2D6 Child, Preschool Child Case-Control Studies priority journal PREVALENCE OXIDATION Male major clinical study insulin dependent diabetes mellitus human Female evaluation ethnic group drug urine level drug metabolism drug hydroxylation drug distribution controlled study childhood disease ARTICLE Debrisoquine cytochrome P450 2D6 4 hydroxydebrisoquine Type 1 diabetes mellitus Cytochrome P<sub>450</sub>IID6
Megjelenés:	Hormone Research. - 61 : 4 (2004), p. 176-179. -
További szerzők:	Barkai László (1958-) (gyermekgyógyász) Sánta Anna Krikovszky Dóra
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat szerző által megadott URL
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