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001-es BibID:	BIBFORM024415
Első szerző:	Madácsy László (Szeged)
Cím:	Association of microalbuminuria with slow acetylator phenotype in type 1 diabetes mellitus / L. Madácsy, I. Szórády, A. Sánta, L. Barkai, I. Vámosi
Dátum:	1992
Megjegyzések:	The genetically determined acetylator phenotype in diabetic children with and without increased urinary albumin excretion was investigated. Acetylator phenotype was determined according to Evans, and 24-hour albumin excretion rate (AER) was measured by immunoturbidometry in 86 children and adolescents with type 1 (insulin-dependent) diabetes mellitus and in 100 age-matched healthy controls. In diabetics, the fast acetylator phenotype was found in 36 (41.9%) patients and the slow one in 50 (58.1%); the control group had 52 (52%) fast and 48 (48%) slow acetylators. There were no significant differences in acetylator phenotypes between diabetic patients and control subjects (?<sup>2</sup> = 1.0, NS). Among patients with normal albumin excretion (n = 70, mean age: 12.9 ? 3.5 years, mean diabetes duration: 5.3 ? 3.8 years, AER < 20 ?g/min), 35 (50%) fast acetylators and 35 (50%) slow acetylators were found. In patients with elevated albumin excretion (n = 16, mean age: 14.0 ? 3.2 years, mean diabetes duration: 4.9 ? 3.0 years, AER > 20 ?g/min), 1 (6.3%) patient was a fast acetylator and 15 (93.7%) were slow acetylators. A significant difference has been found between the two groups in the rate of fast/slow acetylators (?<sup>2</sup> = 8.79, p < 0.01). The strong correlation between the slow acetylator phenotype and microalbuminuria in diabetics suggests that: (a) genetic factors may play a role in the development of diabetic nephropathy; (b) the acetylator status could be a useful tool to detect patients 'at risk' of nephropathy. PubMed ID: 1473091 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-0026676671&partnerID=40&md5=6dc1cdcd56e928db035fd1d29ba23689 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0026676671
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Risk Factors PHENOTYPE Male human Female Diabetic Nephropathies Diabetes Mellitus, Insulin-Dependent Child Albuminuria Adolescent Acetylation microalbuminuria major clinical study insulin dependent diabetes mellitus heredity diabetic nephropathy controlled study ARTICLE acetylator phenotype
Megjelenés:	Child Nephrology and Urology. - 12 : 4 (1992), p. 192-196. -
További szerzők:	Szórády István Sánta A. Barkai László (1958-) (gyermekgyógyász) Vámosi Ildikó
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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