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001-es BibID:	BIBFORM028376
Első szerző:	Liaudet, Lucas
Cím:	Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis / Lucas Liaudet, Csaba Szabó, Oleg V. Evgenov, Kanneganti G. Murthy, Pál Pacher, László Virág, Jon G. Mabley, Anita Marton, Francisco G. Soriano, Mikhail Y. Kirov, Lars J. Bjertnaes, and Andrew L. Salzman
Dátum:	2003
ISSN:	1073-2322
Megjegyzések:	Flagellin is a recently identified bacterial product that elicits immune response via toll-like receptor 5. Here, we demonstrate that flagellin is an extraordinarily potent proinflammatory stimulus in the lung during sepsis. In vitro, flagellin triggers the production of interleukin (IL)-8 by human lung epithelial (A549) cells, with 50% of the maximal response obtained at a concentration of 2 x 10(-14) M. Flagellin also induces the expression of ICAM-1 in vitro. Intravenous administration of flagellin to mice elicited a severe acute lung inflammation that was significantly more pronounced than following lipopolysaccharide (LPS) administration. Flagellin induced a local release of proinflammatory cytokines, the accumulation of inflammatory cells, and the development of pulmonary hyperpermeability. These effects were associated with the nuclear translocation of the transcription NF-kappaB in the lung. Flagellin remained active in inducing pulmonary inflammation at doses as low as 10 ng/mouse. In the plasma of patients with sepsis, flagellin levels amounted to 7.1 +/- 0.1 ng/mL. Plasma flagellin levels showed a significant positive correlation with the lung injury score, with the alveolar-arterial oxygen difference as well as with the duration of the sepsis. Flagellin emerges as a potent trigger of acute respiratory complications in gram-negative bacterial sepsis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban endotoxin shock chemokines bacterial infection inflammation lung külföldön készült közlemény
Megjelenés:	Shock 19 : 2 (2003), p. 131-137. -
További szerzők:	Szabó Csaba (1967-) (orvos) Evgenov, Oleg V. Murthy, Kanneganti G. Pacher Pál Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Mabley, Jon G. Marton Anita Soriano, Francisco Garcia Kirov, Mikhail Y. Bjertnaes, Lars J. Salzman, Andrew L.
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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