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001-es BibID:	BIBFORM029497
Első szerző:	Wolf Ervin (fizikus, neurobiológus)
Cím:	Simulation of the effect of synapses : the significance of the dendritic diameter in impulse propagation / Wolf E., Birinyi A., Székely G.
Dátum:	1992
ISSN:	0953-816X
Megjegyzések:	The effectiveness of synapses at various sites of the dendritic tree was studied using a segmental cable model with a program developed by Hines (Int. J. Biomed. Comput., 24, 55 - 68, 1989). The model rendered possible a high-fidelity simulation of the dendritic geometry of a frog motoneuron described in the accompanying paper (Birinyi et al., Eur. J. Neurosci., 1003 - 1012, 1992). The model was used in the passive membrane mode and the synaptic activity was simulated with current injections into large and small diameter dendrites at proximal and distal locations. Synaptic efficiency was defined by the charge transfer ratio expressed as the proportion of the injected current which appeared at the soma. The charge transfer ratio was determined with uniform and non-uniform distribution of specific membrane resistance over the soma - dendrite surface while the diameter of selected dendrite segments changed. The best charge transfer ratio was found with the largest dendrite membrane resistance, and the maximum efficiency of synaptic activity appeared at the original size of the dendrite segment stimulated. The amount of current that flowed in the proximal and distal directions from the segment stimulated depended on the diameter of that segment. The increase in diameter of proximal dendrites increased synaptic efficiency on distal dendrites, whereas the reverse caused a decline in synaptic efficiency on proximal dendrites. In addition to the diameter of dendrites, the arborization pattern also played a significant role in this mechanism. It is concluded that the cellulipetal increase in dendrite diameter greatly increases synaptic efficiency.
Tárgyszavak:	Orvostudományok Természettudományok Biológiai tudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	European Journal Of Neuroscience. - 4 : 11 (1992), p. 1013-1021. -
További szerzők:	Birinyi András (1960-) (anatómus, neurobiológus) Székely György (1926-2017) (neurobiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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