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001-es BibID:	BIBFORM029922
Első szerző:	Misz Mária
Cím:	Haemostasis eltérések ischaemiás stroke-ban / Misz Mária, Oláh László, Kappelmayer János, Blaskó György, Udvardy Miklós, Fekete István, Csépány Tünde, Ajzner Éva, Csiba László
Dátum:	1998
Megjegyzések:	The authors studied whether haemostatic abnormalities connected with the development of cerebral circulatory disturbances can be demonstrated in young stroke patients in whom Doppler and angiographic examination failed to reveal deviations indicative of stroke. They determined the in vivo activation of the coagulation system (TAT, F 1 + 2), the degree of secondary fibrinolysis (D-dimer), the plasma levels of the markers of fibrinolysis, with special regard to inhibitors: plasminogen activator inhibitor (PAI-1), alfa2 antiplasmin (alfa1 AP), alfa2 macroglobulin (alfa2 M), the frequency of pathologic serum lipoprotein (a) - Lp(a) - values and the association of PAI-1 and Lp(a) with the fibrinolytic system. They conclude that in the acute phase of the disease, the TAT and F 1 + 2 values were significantly elevated compared to the control, without change in the D-dimer value. The results suggest that in the tested period increased thrombin generation dominated and it significantly surpassed plasmin activity since the D-dimer values of that period did not indicate substantial increase in secondary fibrinolysis. The results of the study were separately analyzed in acute, chronic TIA and stroke groups. In the TIA and acute group the F 1 + 2 values, while in stroke the TAT values were more elevated. The in vitro fibrinolytic capacity of the patients significantly decreased compared to controls, showing significantly decreased compared to controls, showing significant correlation with the Lp(a) level, but not with the PAI value. Examination of the marker molecules renders possible to assess the degree of hypercoagulability and of endogenous lysis. Their knowledge is held important for judging the progression of the disease and the therapeutic consequences.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Orvosi Hetilap 139 : 42 (1998), p. 2503-2507. -
További szerzők:	Oláh László (1967-) (neurológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Blaskó György (1947-) (belgyógyász, klinikai farmakológus) Udvardy Miklós (1947-) (belgyógyász, haematológus) Fekete István (1951-) (neurológus, pszichiáter) Csépány Tünde (1956-) (neurológus, pszichiáter) Ajzner Éva (1968-) (laboratóriumi szakorvos) Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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