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001-es BibID:	BIBFORM030275
Első szerző:	Nánási Péter Pál (élettanász)
Cím:	Action-potential duration and contractility in canine cardiac tissues : action of inotropic drugs / Péter P. Nánási, András Varró, David A. Lathrop
Dátum:	1998
ISSN:	0306-3623
Megjegyzések:	1. Inotropic and electrophysiologic effects of veratrine, vesnarinone, d-sotalol and tetraethylammonium (TEA) were compared. Action potential duration (APD) and contractility were measured in isolated canine Purkinje fiber and ventricular trabecular muscle preparations by using standard microelectrode techniques. Each drug significantly increased APD and force development in either tissue. 2. Drug-induced increases in force development were normalized to increases in APD. The order of efficacy was found to be vesnarinone>veratrine>TEA in ventricular myocardium, whereas it was veratrine>>vesnarinone=d-sotalol=TEA in Purkinje fibers. 3. The force-APD relation was linear for all drugs in the concentrations used. 4. Simultaneous measurements of APD, force development and intracellular sodium ion activity (a(Na)(i)) in the presence of either veratrine or lidocaine indicated a linear relation between force development and changes in a(Na)(i). 5. The relation between APD and force development was different in ventricular and Purkinje fiber preparations. Differences in the veratrine sensitivity of the force-APD relation observed between Purkinje and ventricular preparations suggest that a(Na)(i)-dependent changes in Na+/Ca2+ exchange may play a more important role in regulation of force generation in Purkinje fibers than in ventricular myocardium. GEN PHARMAC 31;3:415-418, 1998. (C) 1998 Elsevier Science Inc.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	General Pharmacology. - 31 : 3 (1998), p. 415-418. -
További szerzők:	Varró András (1954-) (farmakológus, klinikai farmakológus) Lathrop, David A.
Internet cím:	DOI elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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