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001-es BibID:	BIBFORM030356
035-os BibID:	(Scopus)0026366026 (WoS)A1991JM65600007 (PMID)1668707
Első szerző:	Nánási Péter Pál (élettanász)
Cím:	Slow membrane potential changes in skeletal muscle induced in Cl(-)-free medium / P. P. Nanasi, M. Danko
Dátum:	1991
ISSN:	0231-424X
Megjegyzések:	1. Conventional microelectrode techniques were used to measure simultaneous changes in membrane potential (V(m)) and conductance (G(m)) induced by single electrical stimuli in muscles bathed in Cl--free solution containing 40 mM of tetraethylammonium (TEA+). 2. Stimulation induced slow transient depolarizations (slow response) accompanied by increased calcium conductance, while the potassium conductance was first elevated and later reduced. 3. Stepwise elevation of [K+]0 from 2.5 to 5 or 10 mM during the slow response evoked an abrupt repolarization of 42.3 +/- 8.9 mV (n = 4; p < 0.001), and 24.8 +/-3.5 +/- mV (n = 5; p < 0.001), respectively, while G(m) was increased to 1.45 +/- 0.25-fold (n = 5; p < 0.05). Neither the slow response nor K+-induced changes in V(m) or G(m) were sensitive to tetrodotoxin (3-mu-M), however, nifedipine (10-mu-M) abolished the slow response. 4. It was concluded that beyond the increase of calcium conductance, the ionic conductance of the inward rectifier K+ channel was reduced during the slow response, which could be restored by the elevation of [K+]0. The results suggest the possible contribution of these mechanisms to the electrical instability of myotonic muscles. Potential therapeutic consequences are discussed.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk egyetemen (Magyarországon) készült közlemény
Megjelenés:	Acta Physiologica Hungarica. - 78 : 4 (1991), p. 369-377. -
További szerzők:	Dankó Miklós
Pályázati támogatás:	1453 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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