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001-es BibID:	BIBFORM030681
Első szerző:	Papp Zoltán (kardiológus, élettanász)
Cím:	How cardiomyocytes make the heart old / Papp Z., Czuriga D., Balogh L., Balogh A., Borbély A.
Dátum:	2012
ISSN:	1389-2010
Megjegyzések:	Naturally occurring decline in cardiovascular reserve with age associates with a combination of the reduction in cardiomyocyte number and altered cardiomyocyte function. Recent investigations suggested that about half of the cardiomyocytes is the same as at birth, while the other half of the cardiomyocytes is the result of cardiomyocyte renewal in the senescent heart. In addition, the total number of cardiomyocytes is estimated to be less by one third in the old heart than the number of cardiomyocytes at birth. Thus, the reduction in cardiomyocyte number of the aging heart cannot be fully compensated by cardiomyocyte renewal. Aging of long-lived differentiated myocardial cells, as well as of cardiac progenitor stem cells may contribute to an increased rate of apoptosis, and decreased capacity of cell duplication and/or differentiation. In addition, differentiated cardiomyocytes are prone for accumulating biological by-products of cellular metabolism and of incompletely processed oxidative insults. In this context, interactions between lysosomes and mitochondria may provide a mechanistic background for the age-dependent alterations in cardiac macromolecules. This reasoning postulates a direct relationship between the number of pro-oxidative, ill-functioning mitochondria and the amount of ballast-overloaded lysosomes in long-lived cardiomyocytes. Accumulation of biological garbage and telomere shortening might be considered as hallmarks of cardiomyocyte aging with implications for depressed cardiac function and cardiomyocyte renewal. Changes in protein expression together with posttranslational modifications of myocardial proteins affect excitation-contraction coupling and explain the declining mechanical function of the cardiomyocytes. Altogether, these changes represent a significant part of the reduced cardiovascular reserve in aged individuals.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány Aging Cardiomyocyte cell death Cardiomyocyte renewal Telomere
Megjelenés:	Current Pharmaceutical Biotechnology. - 13 : 13 (2012), p. 2515-2521. -
További szerzők:	Czuriga Dániel (1982-) (kardiológus) Balogh László (1976-) (kardiológus) Balogh Ágnes (1984-) (kardiológus) Borbély Attila (1978-) (kardiológus)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Vascularis rizikó- és stroke betegek vizsgálata
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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