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001-es BibID:	BIBFORM030696
Első szerző:	Fülesdi Béla (aneszteziológus)
Cím:	Cerebral vasoreactivity to acetazolamide is not impaired in patients with severe sepsis / Béla Fülesdi, Szilárd Szatmári, Csaba Antek, Zoltán Fülep, Péter Sárkány, László Csiba, Csilla Molnár
Dátum:	2012
ISSN:	0883-9441
Megjegyzések:	Introduction: The pathophysiology of sepsis-associated encephalopathy (SAE) is not entirely clear, butone of the possible underlying mechanisms is the alteration of the cerebral microvascular function. Theaim of the present work was to test whether cerebral vasomotor reactivity is impaired in patients withsevere sepsis.Methods: Patients fulfilling the criteria of clinical sepsis and showing at least 2 organ dysfunctions wereincluded (n = 16). Nonseptic healthy persons without previous diseases affecting cerebral vasoreactivityserved as controls (n = 16). Transcranial Doppler blood flow velocities were measured at rest and at 5,10, 15, and 20 minutes after intravenous administration of 15 mg/kg acetazolamide. The time course ofthe acetazolamide effect on cerebral blood flow velocity (cerebrovascular reactivity [CVR]) and themaximal vasodilatory effect of acetazolemide (cerebrovascular reserve capacity [CRC]) were comparedamong the groups.Results: Absolute blood flow velocities after administration of the vasodilator drug did not differbetween control and septic patients. Assessment of the time course of the vasomotor reaction showedthat patients with sepsis reacted in a similar fashion to the vasodilatory stimulus than control persons.When assessing the maximal vasodilatory ability of the cerebral arterioles to acetazolamide duringvasomotor testing, we found that there was no difference in vasodilatory ability between septic andhealthy subjects (CRC controls, 54.8% ? 11.1%; CRC sepsis-associated encephalopathy, 61.1% ?34.4%; P = .49).Conclusions: We conclude that cerebrovascular reactivity is not impaired in patients with severe sepsis.It is conceivable that cerebral vasoreactivity may be differently involved at different severity stages ofthe septic process.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Septic encephalopathy egyetemen (Magyarországon) készült közlemény Cerebral vasoreactivity Acetazolamide
Megjelenés:	Journal of Critical Care 27 : 4 (2012), p. 337-343. -
További szerzők:	Szatmári Szilárd (1984-) (aneszteziológus) Antek Csaba (1967-) (aneszteziológus) Fülep Zoltán (aneszteziológus) Sárkány Péter (1966-) (aneszteziológus) Csiba László (1952-) (neurológus, pszichiáter) Molnár Csilla (1962-) (aneszteziológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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