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001-es BibID:	BIBFORM031277
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Lycopene induces retinoic acid receptor transcriptional activation in mice / Gamze Aydemir, Harald Carlsen, Rune Blomhoff, Ralph Rühl
Dátum:	2012
ISSN:	1613-4125
Megjegyzések:	Lycopene is a lipophilic carotenoid and provides the red color to tomatoes and tomato product. Various studies indicated that lycopene and tomatoes / tomato products are able to positively influence various diseases associated with a chronic inflammation. The mechanism of action of lycopene to elicit these effects is partly unknown. A possible mechanism is that biological metabolites of lycopene may activate nuclear hormone receptors in mammalian cells. The aim of this study was to investigate the potential of orally administered lycopene and all-trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response-element (RARE)-reporter mouse system. Methods and Results:Orally administered lycopene (100 mg/kg bw in beadlets, n=6) and all-trans retinoic acid (ATRA) as an endogenous retinoic acid receptor (RAR)-ligand (50 mg/kg bw, n=6) for the induction of the retinoic acid receptor in male mice using a transgenic retinoic acid response-element (RARE)-reporter mouse system. Lycopene-treatments induced RARE-mediated cell signaling indicated by quantified bio-imaging, increased luciferase activity and up-regulated the retinoid target genes in selected organs of the mice. Conclusion:We conclude that lycopene can induce RAR-transcriptional activation in mice and lycopene might be a precursor of still non identified biologically active metabolites.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban lycopene retinoid signalling külföldön készült közlemény
Megjelenés:	Molecular Nutrition and Food Research. - 56 : 5 (2012), p. 702-712. -
További szerzők:	Carlsen, Harald Blomhoff, Rune Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TÁMOP 4.2.1./B-09/1/KONV-2010-007 TÁMOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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