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001-es BibID:	BIBFORM032943
035-os BibID:	PMID:9076505
Első szerző:	Rusznák Zoltán (élettanász)
Cím:	Characteristics of the ventricular transient outward potassium current in genetic rodent models of diabetes / Z. Rusznák, Z. Cseresnyés, I. Sipos, J. Magyar, L. Kovács, G. Szücs
Dátum:	1996
ISSN:	0231-5882
Megjegyzések:	The whole-cell configuration of the patch-clamp technique was employed to measure the transient outward potassium current in enzymatically isolated ventricular cells of spontaneously diabetic rats (BB/Wor) and mice (ob/ob). Healthy littermates (non-diabetic BB rats and lean mice) were used as controls. There was no significant difference between the non-diabetic and diabetic BB rats (Type I diabetes, IDDM) in the amplitude of either the current measured in the absence or the one found in the presence of 4-aminopyridine. The voltage dependence of the activation and steady-state inactivation was also similar in both populations, as no significant difference was observed in the rate of recovery from inactivation of Ito. The amplitudes of the total and 4-aminopyridine sensitive currents of lean and obese mice (Type II diabetes, NIDDM) were also similar. The voltage dependences of the activation and of the steady-state inactivation did not differ significantly, either. Our results might indicate certain limitations of the applicability of experiments carried out on genetically diabetic rats if the results are compared to those derived from the healthy littermates as controls.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	General Physiology And Biophysics 15 : 3 (1996), p. 225-238. -
További szerzők:	Cseresnyés Z. Sipos István Magyar János (1961-) (élettanász) Kovács László (1939-) (élettanász) Szűcs Géza (1948-) (élettanász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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