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001-es BibID:	BIBFORM032945
035-os BibID:	(Scopus)0030473470 (WoS)A1996VZ33500012 (PMID)8967973
Első szerző:	Magyar János (élettanász)
Cím:	Effects of volatile anesthetics on the G protein-regulated muscarinic potassium channel / János Magyar, Gábor Szabó
Dátum:	1996
ISSN:	0026-895X
Megjegyzések:	The muscarinic-activated K+ channel K(ACh), a prototype of channels regulated by neuroendocrine agonists via G proteins, was used to investigate the mode of action of isoflurane and halothane on G protein-coupled signal transduction processes. The evolution of the muscarinic current I(K(ACh)) was characterized through rapid agonist application and washout. At physiologically relevant concentrations, halothane and isoflurane reduced the rate of I(K(ACh)) activation without comparable effects on deactivation. Furthermore, both anesthetics reduced or eliminated the spontaneous decay (rapid desensitization) typical of the muscarinic response. In contrast to these similarities of anesthetic action on the time course of the response, the magnitude of I(K(ACh)) was slowly reduced by isoflurane but rapidly augmented by halothane. Neither halothane nor isoflurane altered the conductance of single I(K(ACh)) channels, indicating that these volatile anesthetics act on channel open-close kinetics. The reduced I(K(ACh)) activation rates suggest that impaired receptor/G protein interactions are induced by both anesthetics. For halothane, the increased amplitude of the response, also seen for I(K(ACh)) activated in a receptor-independent manner by guanosine-5'-O-(3-thio)triphosphate, suggests a direct action on the channel. Alteration of signal transduction processes by halothane and isoflurane may underlie some anesthetic actions of these compounds as well as secondary effects on the cardiovascular system.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Molecular Pharmacology. - 50 : 6 (1996), p. 1520-1528. -
További szerzők:	Szabó Gábor (orvos)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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