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001-es BibID:	BIBFORM033105
035-os BibID:	(Scopus)74349086293 (WoS)000276927300019 (PMID)19816227
Első szerző:	Csomor Péter (biotechnológus)
Cím:	TNF-[alpha] receptor expression correlates with histologic activity of otosclerosis / Péter Csomor, István Sziklai, Tamás Karosi
Dátum:	2009
ISSN:	1531-7129
Megjegyzések:	HYPOTHESIS:Otosclerosis is an inflammatory bone remodeling disorder of the human otic capsule, which might be characterized by variable levels and unique expression pattern of TNF-alpha receptors.BACKGROUND:Histologic characteristics of otosclerosis have been well described during the latest decades; however, the grading of different histopathologic and clinical stages has not been attributed precisely to the molecular biology of the pathologically increased metabolism of osteoclast-osteoblast axis.METHODS:Forty otosclerotic- and 40 nonotosclerotic ankylotic stapes footplates (n = 80; men, 29; women, 51) were histologically analyzed: conventional hematoxylin-eosin staining and tumor necrosis factor-alpha receptor I and II (TNFRI/II)-specific immunofluorescent assay was performed.RESULTS:Active otosclerosis (Grades I-II; n = 24) was featured by increased expression of TNFRII and moderate expression of TNFRI; inactive cases (Grades III-IV) were characterized by permanent expression of TNFRI; however, TNFRII-specific immunoreaction was absent. Nonotosclerotic stapes specimens showed a negligible TNFR expression. Tumor necrosis factor receptor expression pattern showed a strong correlation with the histologic activity of otosclerosis (chi2 test; p < 0.001).CONCLUSION:Detection of elevated TNFR expression demonstrates activated osteoclast metabolism and inflammatory pathways in otosclerosis. Different etiopathogenesis of otosclerotic and nonotosclerotic stapes ankylosis should be distinguished. Administration of monoclonal anti-TNF-alpha antibody may be a reasonable option in the medical treatment of active stages of otosclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban TNF-alpha Otosclerosis inflammation Non othosclerosis tumor necrosis factor alpha tumor necrosis factor alpha receptor egyetemen (Magyarországon) készült közlemény
Megjelenés:	Otology and Neurotology. - 30 : 8 (2009), p. 1131-1137. -
További szerzők:	Sziklai István (1954-) (fül-orr-gégész) Karosi Tamás (1979-) (fül-orr-gégész)
Pályázati támogatás:	OTKA PD75371 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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