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001-es BibID:	BIBFORM033137
Első szerző:	Karosi Tamás (fül-orr-gégész)
Cím:	Tumor necrosis factor-alfa receptor expression correlates with mucosal changes and biofilm presence in chronic rhinosinusitis with nasal polyposis / Karosi Tamás, Csomor Péter, Sziklai István
Dátum:	2012
ISSN:	0023-852X
Megjegyzések:	OBJECTIVES/HYPOTHESIS: Biofilms might play a potential role in the pathogenesis and high recurrence rate of chronic rhinosinusitis with nasal polyposis (CRSwNP). Biofilm persistence has been thought to correlate with epithelial damage, subepithelial inflammatory cell infiltration, and tumor necrosis factor-? receptor (TNFR) expression in CRSwNP.STUDY DESIGN:Case-control experimental study.METHODS:A total of 36 patients with CRSwNP undergoing endoscopic sinus surgery were analyzed. The negative control group consisted of eight patients undergoing septoplasty for nasal obstruction without CRSwNP. The nasal polyps and inferior turbinate mucosa samples applied as negative controls were processed by hematoxylin-eosin (HE) and Gram staining and TNFR-I and TNFR-II-specific immunofluorescent assay.RESULTS:Biofilm was detected in 29 of 36 patients with CRSwNP and in none of the eight negative controls. Staining by HE showed strong correlation with the results of Gram staining protocol. In the biofilm-positive cases, TNFR-I and TNFR-II displayed homogeneous pattern of significantly increased epithelial expression compared to the biofilm-negative nasal polyps. In cases of biofilm absence, the expression pattern of TNF-? receptors was characterized by increased TNFR-II-specific immunoreaction. It was found that biofilm detectability corresponded to the integrity of nasal epithelium and to the dominant inflammatory cell type of the subepithelial layer.CONCLUSIONS:Persisting biofilms might increase the epithelial sensitivity against TNF-? that result in epithelium destruction. Coexistence of biofilms and increased TNFR expression might explain the inflammatory mucosal changes, functional disorders, and therapy resistance featuring CRSwNP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Biofilm chronic rhinosinusisitis nasal polyps tumor necrosis factor-alpha receptors
Megjelenés:	Laryngoscope. - 122 : 3 (2012), p. 504-510. -
További szerzők:	Csomor Péter (1984-) (biotechnológus) Sziklai István (1954-) (fül-orr-gégész)
Pályázati támogatás:	OTKA PD75371 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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