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001-es BibID:BIBFORM033340
Első szerző:Walter, Peter
Cím:Cortical activation via an implanted wireless retinal prosthesis / Peter Walter, Zoltán F. Kisvárday, Michael Görtz, Nils Alteheld, Gernot Rossler, Thomas Stieglitz, Ulf T. Eysel
Dátum:2005
ISSN:0146-0404
Megjegyzések:PURPOSE: To demonstrate local cortical activations in the primary visual cortex of the cat as a result of retinal electrical stimulation by means of a completely wireless-controlled, implantable retinal prosthesis in a series of acute experiments. METHODS: The transfer of energy to drive the device and signals to activate any combination of 25 retinal electrodes was achieved completely wirelessly by an external transmitter positioned in front of the eye. Individually configured electrical stimuli were applied via any combination of 25 electrodes, on sending the necessary pulse parameters to the implant. Placement of the implant onto the retinal surface was achieved after lensectomy and vitrectomy in the cat. Fixation was performed with a retinal tack. Cortical activation patterns were recorded by means of optical imaging of intrinsic signals. RESULTS: Implantation and fixation were successfully performed in three cats. Wireless activation of the implant by radiofrequency was demonstrated by recording of stimulus artifacts from the sclera. Local activation of the visual cortex measured by optical imaging of intrinsic signals revealed a shift of cortical response that was well correlated with a change in the position of the activated retinal electrodes. CONCLUSIONS: The results demonstrate the retinotopic activation of the visual cortex using a completely wireless, remote-controlled retinal implant.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
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Megjelenés:Investigative Ophthalmology & Visual Science. - 46 : 5 (2005), p. 1780-1785. -
További szerzők:Kisvárday Zoltán (1957-) (biológus, neurobiológus) Görtz, Michael Alteheld, Nils Rossler, Gernot Stieglitz, Thomas Eysel, Ulf T.
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