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001-es BibID:	BIBFORM033429
Első szerző:	Kisvárday Zoltán (biológus, neurobiológus)
Cím:	Synaptic connections of axo-axonic (chandelier) cells in human epileptic temporal cortex / Z. F. Kisvárday, C. B. Adams, A. D. Smith
Dátum:	1986
ISSN:	0306-4522
Megjegyzések:	The human temporal cortex contains a type of interneuron, identified by Golgi impregnation which, like the axo-axonic or chandelier cells found in animals, establishes Gray's type II synaptic contacts exclusively with the axon initial segments of pyramidal cells. Each terminal segment is composed of 3-12 boutons to form a "chandelier"-like appearance. For the two human axo-axonic cells analysed in this study we could identify 269 and 86 bouton rows respectively, which represents an equivalent number of postsynaptic pyramidal cells. A terminal bouton row from one of these Golgi-impregnated cells was shown to be in synaptic contact with the axon initial segment of a Golgi-impregnated pyramidal cell. The very specific nature of the target of axo-axonic cells, together with their highly divergent axonal arborization, means that they are ideally placed to control the output of a large population of pyramidal cells. Since previous studies in animals have shown the GABAergic nature of axo-axonic cells it is possible that human axo-axonic cells could be involved in the generation of epileptic activity or in the control of its propagation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Neuroscience. - 19 : 4 (1986), p. 1179-1186. -
További szerzők:	Adams, C. B. T. Smith, A. David
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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