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001-es BibID:	BIBFORM033450
Első szerző:	Trapp, Torsten
Cím:	GTPase RhoB : an early predictor of neuronal death after transient focal ischemia in mice / Trapp T., Oláh L., Hölker I., Besselmann M., Tiesler C., Maeda K., Hossmann K. A.
Dátum:	2001
ISSN:	1044-7431
Megjegyzések:	Applying the recently developed DNA array technique to a murine stroke model, we found that the gene coding for RhoB, a member of the family of GTPases that regulate a variety of signal transduction pathways, is upregulated in ischemia-damaged neurons. RhoB immunoreactivity precedes DNA single-strand breaks and heralds the evolving infarct, making it an early predictor of neuronal death. Expression of RhoB colocalized with drastic rearrangement of the actin cytoarchitecture indicates a role for Rho in postischemic morphological changes. Apoptosis in a murine hippocampal cell line was also associated with an early increase in RhoB protein. Activation of caspase-3, a crucial step in apoptosis, could be inhibited by cytochalasin D, a substance that counteracts the actin-modulating activity of Rho GTPases, indicating that Rho proteins may have impact on injury-initiated neuronal signal transduction. Our findings make Rho GTPases potential targets for the development of drugs aimed at limiting neuronal death following brain damage.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Molecular And Cellular Neuroscience. - 17 : 5 (2001), p. 883-894. -
További szerzők:	Oláh László (1967-) (neurológus) Hölker, Irmgard Besselmann, Michael Tiesler, Christine Maeda, Keiichiro Hossmann, Konstantin-Alexander
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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